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08-13-2008, 06:33 AM
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#1
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Breast cancer cells evade HER-targeted therapy
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08-13-2008, 07:39 AM
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#2
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Webmaster
Join Date: Feb 2005
Location: Home of the "Flying Tomato"
Carlsbad, CA
Posts: 2,036
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Tykerb addresses this problem by inhibiting both HER1 and 2 pathways.
Dr. Kent Osborne is expected to shortly start a new clinical trial using 3 drugs which inhibit all of the HER2 pathways. I will try and email him to see what the status of this trial is.
Regards
Joe
__________________
A Proud webmaster to the internet's most informed, educated, COMPASSIONATE and caring group of breast cancer survivors.
Illegitimi non carborundum
My Album
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08-13-2008, 10:40 AM
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#3
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Senior Member
Join Date: Oct 2005
Posts: 3,519
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Thanks JOE! You know I have been keen to keep an eye on Dr Osborne's progress... let me know if I need to camp out at his office door to get some info!
__________________
Brenda
NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)
Nov'03~ dX stage 2B
Dec'03~ Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~ Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~ micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~ micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg
Apr'07~ MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~ Started Tykerb/Xeloda, no WBR for now
June'07~ MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~ MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~ PET/CT & MRI show NED
Apr'08~ scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~ MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~ dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~ Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~ new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~ new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~ 25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.
"I would rather be anecdotally alive than statistically dead."
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08-13-2008, 03:10 PM
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#4
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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I still think there are other "drivers" of the cancer, such as hormones, that need to be considered.
Many of us who can't get control, or KEEP control, of our tumors have to have other biological factors at work then the HER family of 4 pathways. Look how many of our members did not do well with Tykerb and other new drugs, rest their souls.
At the American Society of Cancer Researchers Annual Meeting in San Diego I met more than one person who was already at work at studying WHY Tykerb had better results in mice than people.
When I discussed this a bit with them they both (and they were not working together) said that one of the difficulties with this is that more discoveries are being made about what gets the cancer started in the first place, and they are waiting for these studies.
The amount of research going on is really incredible, as they get deeper and deeper into the cancer molecules.
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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08-13-2008, 06:11 PM
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#5
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Senior Member
Join Date: Sep 2005
Posts: 589
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Just an fyi that as much hype as Tykerb has gotten I can tell you that I know of one renowned dr who feels very strongly that it's overhyped and pertuzamab is a much better drug. This carries a great deal of weight for me since this onc's hospital doesn't have access to pertuzamab.
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11-14-2008, 04:26 PM
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#6
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Member
Join Date: Oct 2008
Location: Houston, Texas
Posts: 9
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Joe, Was this trial ever posted? I am a new patient of Dr. Osborne's and have just started Taxol/Herceptin with him.
__________________
DX DCIS Left Breast 6/08
Bi-lateral Mastectomy 9/08
Node Negative
Found IDC <1cm (.4cm)
ER+ PR+ HER2+
BRAC1/2-
37 years old
Mom died of BC at 38
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11-15-2008, 11:06 PM
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#7
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Senior Member
Join Date: Aug 2008
Posts: 327
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Article/study
Hopeful,
I couldn't open the article, said 'page not found'.
The study is a bit over my head. Anyone care to comment? Does the study indicate that Herceptin is not targeting the cells or that cancer cells are evading 'targeted therapy'?
Diannes
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11-21-2008, 04:44 PM
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#9
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Senior Member
Join Date: Aug 2008
Posts: 327
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I would be interested in watching this thread.
From what I could gather from the article - I'm no scientist - it sounds as if Herceptin (the monoclonal antibody mentioned) does have some effect?
Only problem is, patients like me don't know if it has attached to their immune system or not. Seems like they would have some type of blood test to determine that. They can check to see if a person has hepatitis antibodies, why not herceptin?
Diannes
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