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05-02-2011, 04:57 PM
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#1
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Senior Member
Join Date: Sep 2005
Location: St. George, UT
Posts: 582
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Halavan---So far, so good!
I had my first halavan chemo last Tuesday and will have the second tomorrow. So far it seems to be good news---no nausea, some extra itching but so far no new hives, am able to sleep and eat, just extra tired. However my two oldest daughters are visiting and we are staying up late and doing more. My husband and I even drove to Las Vegas (an hour and a half away) to pick one daughter up from Houston, at the Las Vegas airport. It was a long day but I slept well and had no after effects. I have a good appetite (a first with any chemo!) and hope to gain back a few pounds I've lost. I am amazed at how short the halavan infusion is: only an hour including anti-nausea med, allergy med and a hydration treatment. The actual halavan infusion itself is less than 5 minutes long! I am uneasy that I am unable to add herceptin, but guess there is no info on doing the two together. Besides, my ejection fraction has dropped to 45 and my onclogist won't give me herceptin unless my ef is over 50. Since we did try herceptin alone after the problems with other chemos, he seems to feel that the herceptin doesn't work now for me. But my concern is whether the her2 cancer can be stopped without herceptin. Anyone have comments on that?
I am noticing some irregular heart beats and higher pulse, plus the extra fatigue and dizziness. The oncologist said to watch for those and also any indication of fever or immune problems. I have blood tests the day before the chemo so the onc is aware of how I am doing. I am not sure how many weeks the halavan treatment is given, but it is once a week. I know the first infusion doesn't always tell the tale so I will let you know how the second and third do. It was such a help to have the info and experiences available here! As always I am so grateful for this website and all the kindness and concern shown here. Even when I don't have time to post, I always read the new posts and send out a prayer and love for each writer. Thank you all for being there and special appreciation to Christine and her family. Hugs, TriciaK
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05-02-2011, 06:08 PM
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#2
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: Halavan---So far, so good!
That is great! Thank you so much for letting us know the first infusion went well. Hugs to you also.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement （600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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05-02-2011, 11:56 PM
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#3
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Senior Member
Join Date: Feb 2007
Location: Paris, France
Posts: 858
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Re: Halavan---So far, so good!
Tricia, I am happy that you have no nausea and no hives with this new treatment. This is good news! Hugs. Michka
__________________
08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex
12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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05-03-2011, 07:35 AM
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#4
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Re: Halavan---So far, so good!
Tricia
So glad to read your post on the Halaven...I am waiting to get mine right now. Mine takes 5 minutes as I do not get fluids with mine. I get mine day 1 and day 7 then skip a week...it is a 21 day cycle...I also get Herceptin day 7 and have had no problem. There are several now getting both drugs where I get treatment. I do have to take Lisinopril and Coreg to keep my LVEF up above 50. hope the Halaven continues to work for you....watch the white counts, they crash fast, sending love and a hug...you are a trooper!
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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05-03-2011, 12:00 PM
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#5
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Senior Member
Join Date: May 2006
Posts: 3,142
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Re: Halavan---So far, so good!
I am so glad Halaven seems to be working for you. Sheila is the one to talk to about Halaven. She was our first gal to get it, so she has the most experience with it.
Take good care of yourself. Maybe your doc will consider some of the drugs Sheila is taking for her heart during Halaven since you think you have some heart issues.
I have taken prescription grade Co Enzyme Q 10 since my diagnosis. I never had a low LVF or any problems with my heart. Mine has always been above 50. Currently it is 55-60. My docs always comment about my strong heart beat.
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05-04-2011, 07:34 PM
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#6
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Senior Member
Join Date: Oct 2007
Posts: 1,851
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Re: Halavan---So far, so good!
Tricia,
I'm glad you're feeling okay while on the Havalen, and that you can take it and then add back the Herceptin when your ejection fraction improves. Sounds like you're having a great visit with your daughters!
Hugs,
Joan
__________________
Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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05-18-2011, 04:48 PM
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#7
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: Halavan---So far, so good!
Breast Cancer Trials (breastcancertrials.org) just added Halavan to its list today:
"We added Halaven®/Eribulin (Chemotherapy) and Prolia®/Denosumab (Biological Therapy for Bone Mets), two newly approved drugs, to our treatment section.
· On the Metastatic Health History form, we added four new options to "sites with current evidence of disease": breast, chest wall, skin, and ovaries, in order to match to trials more accurately.
· We added a feature whereby studies that do not require visits to a research site are placed at the top of your "My Trials" list. Eligible participants can live anywhere in the United States and participate from home.
Please continue to Contact Us with your comments and suggestions. Your feedback helps us improve our service.
Sincerely,
The BCT Team"
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement （600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
Last edited by Jackie07; 05-18-2011 at 05:33 PM..
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