Tamoxifen, LHRH agonist, AI, oophorectomy??

[jane2638]

Dear all,

I started the "Tamoxifen anxiety" thread nearly two months ago, when I was starting chemo. Two months later, I'm still unsure how to proceed. There are a couple of articles out there that argue that her2neu, ER+/PR- cancers like mine are highly likely to be resistant to Tamoxifen. Since I am perimenopausal, my alternatives are 5 years on Zoladex, and an oophorectomy followed by an AI. My onc is recommending 2-3 years on Tamoxifen, followed by testing to see if I've gone through menopause, followed by an AI if I have. But I'm not sure I want to take the risk of 2-3 years on Tamoxifen if my cancer is resistant. The cancer center where I am does not do CP2DY6 (?) testing. I got some very useful responses from the previous thread so am hoping for the same this time. Any thoughts?

I still don't know how to do a signature, but my cancer was diagnosed in Oct. 2011, 0.7 cm, node negative, stage 1, grade 3, her2+, ER+/PR-. I am 49.

Thanks!
Jane