HonCode

Go Back   HER2 Support Group Forums > Inflammatory Breast Cancer
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 03-12-2011, 12:41 AM   #1
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,757
ALERT1: higher rate of contralateral (other breast) bc in those with IBC vs non-IBCbc

Breast Cancer Res Treat. 2011 Mar 9. [Epub ahead of print]
Inflammatory breast cancer: high risk of contralateral breast cancer compared to comparably staged non-inflammatory breast cancer.
Schairer C, Brown LM, Mai PL.

Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Room 8026, MSC 7244, Rockville, MD, 20852-7244, USA, schairec@exchange.nih.gov.
Abstract
Inflammatory breast cancer (IBC), the most lethal form of breast cancer, has characteristics linked to higher risk of contralateral breast cancer. However, no large studies have examined risk of contralateral breast cancer following IBC. We calculated absolute risk of invasive contralateral breast cancer among 5,631 IBC and 174,634 comparably staged non-IBC first breast cancer cases who survived at least 2 months following diagnosis and were reported to 13 Surveillance, Epidemiology, and End Results (SEER) registries between January 1, 1973 and December 31, 2006. We considered that contralateral cancers occurring within 2-23 months of first cancer diagnosis may more likely be metastatic/recurrent disease and those occurring 2 or more years after diagnosis independent primaries. Absolute risk of contralateral breast cancer was generally greater following IBC than regional/distant non-IBC, regardless of age and hormone receptor status of first cancer diagnosis. Much of the increase in absolute risk following IBC occurred within 2-23 months of first cancer diagnosis, while the risk for non-IBC occurred more gradually over time since diagnosis. For instance, among women first diagnosed before age 50, absolute risks following IBC and non-IBC were 4.9 vs. 1.1% at 2 years, 6.0 vs. 2.2% at 5 years, and 7.7 vs. 6.1% at 20 years after diagnosis. However, patterns of higher risk following IBC than non-IBC were also evident for at least 10-15 years in the subcohort of women who survived at least 24 months without a contralateral cancer. In conclusion, our results suggest that IBC has higher risk of cancer in the contralateral breast than comparably staged non-IBC, possibly due to both metastatic/recurrent disease and independent primaries.

PMID: 21390499 [PubMed - as supplied by publisher]
Lani is offline   Reply With Quote
Old 09-20-2011, 10:18 AM   #2
shellusea
Junior Member
 
shellusea's Avatar
 
Join Date: Oct 2010
Location: Quebec, Canada
Posts: 4
Re: ALERT1: higher rate of contralateral (other breast) bc in those with IBC vs non-I

Pretty interesting!
Thanks for sharing!
__________________
IBC DxJan.2009 (49yrs)
stageIIIB er-pr-Her+++
4 A/C, 12 Taxol&Herceptin
MRM clear margin, 6+/24 nodes
35 Rads with bolus
1 year Herceptin finish Sept.2010
Neratinib trial April to July 2011
Now enjoying life!
shellusea is offline   Reply With Quote
Old 06-25-2012, 02:56 PM   #3
Unregistered
Guest
 
Posts: n/a
Re: ALERT1: higher rate of contralateral (other breast) bc in those with IBC vs non-I

I had second primary in other side within 14 months of first diagnosis of ibc....
  Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On

Forum Jump


All times are GMT -7. The time now is 05:18 AM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2019, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007
free webpage hit counter