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Old 09-10-2010, 02:16 PM   #1
AlaskaAngel
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Location: Alaska
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bc treatment followed by metabolic syndrome

http://www.cancernetwork.com/display.../10165/1646881
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Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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Old 09-11-2010, 07:28 PM   #2
Laurel
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Location: Hershey, PA. Live The Sweet Life!
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Re: bc treatment followed by metabolic syndrome

Depressing.....
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Laurel


Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara

11 Years NED
I think I just might hang around awhile....

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Old 09-11-2010, 07:46 PM   #3
AlaskaAngel
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Re: bc treatment followed by metabolic syndrome

Hi Laurel,

It is. We want the best possible treatment, and we need to know that whoever is planning it isn't so specialized that they are so focused on just blasting the cancer that they haven't investigated and tracked more thoroughly what the "net" effect is long-term in terms of the endocrine system and our metabolism.

Because most early stage breast cancer patients survive more than 10 years, the two aspects that are particularly important are the target patient population (the vast majority of bc patients are over age 50 and subject to complications like metabolic syndrome), and the risk versus benefit for patients with early stage bc (the majority of whom are NOT at risk for recurrence to begin with). We really NEED endocrinologists to have genuine authority as full members of the team (our tumor board) that makes the initial recommendations for our treatment plan, so that everyone understands who is truthfully most likely to get any benefit and who is not, and why.

This is yet another reason why it would be good to at least consider using trastuzumab alone rather than including chemotherapy, since it is the chemotherapy that is putting us at risk for later development of such problems as metabolic syndrome -- and weight gain that is particularly difficult to reverse and is a major risk factor for recurrence.

AlaskaAngel
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED

Last edited by AlaskaAngel; 09-11-2010 at 07:50 PM..
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