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02-21-2013, 01:36 PM
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#1
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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New Drug for Vaginal Atrophy
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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02-25-2013, 01:58 PM
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#2
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Senior Member
Join Date: Apr 2008
Posts: 1,477
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Re: New Drug for Vaginal Atrophy
Thanks for posting.
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04-28-2013, 11:47 AM
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#3
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: New Drug for Vaginal Atrophy
What I don't quite understand about ospemifene is whether or not it is so different in some way from tamoxifen (which is also a SERM where the estrogen receptors bind to the drug) that it either does or doesn't offer the same benefit as tamoxifen (PLUS help with VVA).
Lani, can you help with this question?
A.A.
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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04-28-2013, 07:35 PM
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#4
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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New SERM for Vaginal Atrophy MAY be a tx for bc in the future
Testing of ospemiphene and 4-hydroxyospemifene in mice:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246110/
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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06-25-2013, 09:01 PM
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#5
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Junior Member
Join Date: Jun 2013
Posts: 2
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Re: New Drug for Vaginal Atrophy
What can you safely take if you have vaginal atrophy and you are ER+. I can't take my Estreace any more and I will have UTIs now.
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06-26-2013, 06:31 AM
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#6
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Re: New Drug for Vaginal Atrophy
pbixler, I am ER+ PR+, and my breast surgeon prescribes Vagifem tablets for me, they are ultra low dose and work very well. Here is a link to a research paper on it: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234898/
I have used very small amounts of Estrace in the past, and found that I had some systemic side effects from it. I have no side effects at all from the Vagifem.
I asked my gynecologist about ospemifene when I saw her last month, as she participated in a research study on it. She said it was not on the market yet, but if I was interested in switching to it when it came available, she would write for it. I am contemplating that. She expected it to be available sometime this summer.
Hopeful |
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06-26-2013, 08:24 PM
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#7
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Junior Member
Join Date: Jun 2013
Posts: 2
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Re: New Drug for Vaginal Atrophy
I visited my gyno today. And she prescribed ospemifene. I will let you know how is goes. It has now been approved.
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06-27-2013, 06:22 AM
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#8
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Re: New Drug for Vaginal Atrophy
Ospemifene is marketed as Osphena. Here is a link to their website: http://www.osphena.com/
pbixler, please let us know how you do on this drug. Best of luck with your treatment.
Hopeful |
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