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Cardiac toxicity with Herceptin
Hi all,
I would like to know if you have experience with decreased ejection fraction secondary to Herceptin and if you were able to resume Herceptin if the drug was temporarily discontinued. Unfortunately I was diagnosed with left-sided HER2+, invasive lobular breast cancer which is ER + and PR- In August 2013. I have received cardio toxic drugs including Adriamycin
. AC every 3weeks x4
. Taxol and Herceptin every week x12
. Radiation x34 doses
.Femara daily x5 years (recently initiated)
I started single dose Hercetin in April, and have received 6 doses. Plan was to have every 3 weeks for a year. now my EF =48%!! Was 80% prior to any treatment, then 70% at start of Taxol and Herceptin, then 62% in May and now in aug 2014, 48%!
I worried about Herceptin resistence but I really never considered cardio toxicity. Now I am feeling that the rug has literally been pulled from under my feet. Nothing I can do to improve my ejection fraction and I worry that the prognosis without Herceptin is markedly worse.
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