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Re: Why Capecitabine and Exemestane?
Affinitor is used in combination with Aromosin because in ER+/Her2 negative bc when Armidex or Femara has failed. It's the way the study was run and nothing more. Generally, the biochemical reaction in the body to inhibit the conversion androgens to estrogen is by inhibiting aromotase ( the catalyst for this reaction). Armidex and Femara use the same mechanism for this. Aromosin inhibits in a different mechanism.
I think your Xeloda question has a similar answer. Xeloda inhibits the synthesis of dna by inhibiting a chemical needed. It works differently than the other drugs mentioned and so the combo has a bigger punch by shutting down multiple mechanisms on reproduction.
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Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Hybrid Mode
