could chronic inflammation from adjuvants used in vaccines be responsible for her2+

[Lani]

breast cancer

the following article is open access (free to all)

just go to google, type in entrez pubmed and type the PMID number below into the address bar

BMC Cancer. 2009 Jan 14;9(1):19. [Epub ahead of print]

Freund's vaccine adjuvant promotes Her2/Neu breast cancer.

Cotroneo MS, Haag JD, Stapel NR, Waller JL, Woditschka S, Gould MN.
ABSTRACT: BACKGROUND: Inflammation has been linked to the etiology of many organ-specific cancers. Indirect evidence suggests a possible role for inflammation in breast cancer. We investigated whether the systemic inflammation induced by Freund's adjuvant (FA) promotes mammary carcinogenesis in a rat model in which cancer is induced by the neu oncogene. METHODS: The effects of FA on hyperplastic mammary lesions and mammary carcinomas were determined in a neu-induced rat model. The inflammatory response to FA treatment was gauged by measuring acute phase serum heptaglobin. In addition, changes in cell proliferation and apoptosis following FA treatment were assessed. RESULTS: Rats receiving FA developed twice the number of mammary carcinomas as controls. Systemic inflammation following FA treatment is chronic, as shown by a doubling of the levels of the serum biomarker, haptoglobin, 15 days following initial treatment. We also show that this systemic inflammation is associated with the increased growth of hyperplastic mammary lesions. This increased growth results from a higher rate of cellular proliferation in the absence of changes in apoptosis. CONCLUSIONS: Our data suggests that systemic inflammation induced by Freund's adjuvant promotes mammary carcinogenesis. It will be important to determine whether adjuvants currently used in human vaccines also promote breast cancer.
PMID: 19144184

Freund's adjuvant

http://en.wikipedia.org/wiki/Freund%27s_adjuvant

Interesting - this adjuvant is apparently not used inhumans but interesting that oxidative stress contributes to BC.

Excess Omega 6 arguably promotes oxidative stress.

[Christine MH-UK]

I notice that Wikipedia says Freund's adjuvant not used on humans due to toxicity.

I think it is really important not to speculate too much regarding vaccines, since it can cause major problems. A British scientist a few years back conducted a study which seemed to link vaccines and autism. This research has been disproven and more recent research suggests that the rise in autism may be mainly to be down to the rising age of parents. Unfortunately, Britain now is having problems with measles because of the lack of vaccination.

More research is needed.

[Lani]

says just that!!