Overexpression of OLC1 Gene Associated with Smoking-Related Lung Cancer The Overexpressed in Lung Cancer 1 (OLC1) gene is expressed at high levels in the majority of lung cancers, more often in samples from smokers than nonsmokers, and its expression is increased in cells treated with cigarette smoke. Smoking increases the risk of lung cancer, but the mechanisms by which smoke triggers tumor formation are unknown. In earlier experiments, Shujun Cheng, M.D.
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