http://theoncologist.alphamedpress.o...print/11/7/742
Herb-Drug Interactions in Oncology: Focus on Mechanisms of Induction
(This information is current as of December 2, 2006)
This a detailed & highly technical description of the interactions (often negative) between some supplements or foods (such as grapefruit) & chemo drugs.
It deals with the roles of
nuclear receptors, such as the pregnane X receptor(XPR), the constitutive androstane receptor,and the vitamin D-binding receptor as well as with that of the metabolizing enzyme CYP3A4 (part of the P450 family).
Two tables are of particular interest:
Table 1:
Metabolizing enzymes involved in the metabolism of chemotherapeutic drugs [15, 85–87]
Table 3:
Potential of complementary and alternative medicines (CAM) to activate nuclear receptors and to induce metabolizing enzymes
(List of selected supplements & foods & whether or not they may interact with chemo)
Threaded Mode