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Old 10-09-2011, 03:47 PM   #1
rachelhmmd
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Does cancer treatment age you?

Since my treatment (taxol/herceptin, bilateral mastectomy and DIEP reconstruction, oopherectomy and AI), beginning two years ago, I feel like I've aged a decade. I'm not sure if it's my "supermenopause," the aftermath of chemo, the stress of the whole ordeal or the constant anxiety about recurrence. When I look in the mirror, or at a photo, I see a much older woman. I still exercise, work full time, but I am always more tired.

Have others experienced this? And, if so, what have they done to remedy it?
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Old 10-09-2011, 03:57 PM   #2
NEDenise
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Re: Does cancer treatment age you?

Oh yes! 0y skin alone looks 10 tears older. My bones and joints feel even older. I absolutely think that super-menopause at 46 has taken a toll.
Once I off the treatment treadmill...I'll be eating good foods, moisturizing constantly, and doing lo impact exercise to rejuvenate my skeleton.

I'm hoping to start January 1st! New Year's resolution? Nah...New Shot at Life Resolution!!
Denise
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1/11-needle biopsy
2/11-Lumpectomy/axillary node dissection - Stage 3c, ER/PR-14/17 nodes
3/11 - Post-op staph infection,cellulitis, lymphedema,seroma,ARRRGH!
4/12/11-A/C x 4, then T/H x 4, H only,Q3 weeks
8/26/11 finished Taxol!!!
10/7/11 mastectomy/DIEP recon
11/11 radiation x28
1/12/12 1st CANCER-VERSARY!
1/12 Low EF/Herceptin "Holiday" :(
2/12 EF up - Back on Herceptin, heart meds
4/2/1212 surgery to repair separated incision from DIEP recon
6/8/12 Return to work :)
6/17/12 Fall, shatter wrist,surgery to repair/insert plate :(
7/10/12 last Herceptin
7/23/12 Brain Mets %$&#! 3cm and 1cm
8/10/12 Gamma knife surgery, LOTS of steroids;start H/Tykerb
8/23/12 Back to work
12/20/12 Injure back-3 weeks in wheel chair
1/12/13 2nd CANCER-VERSARY!
1/14/13 herniate disk in back - surgery to repair
1/27/13 Radiation necrosis - edema in brain - back on steroids - but not back to work - off balance, poor cordination in right arm
5/3/13 Start Avastin to shrink necrosis
5/10/13 begin weaning steroids
6/18/13 Brain MRI - Avastin seems to be working!
6/20/13 quarterly CT - chest, abdomen, pelvis - All Clear!
7/5/13 finally off steroids!!
7/7/13 joined the ranks of the CHEMO NINJAS I am now Tekuto Ki Ariku cancer assassin!
7/13/13 Symptoms return - back on steroids
7/26/13 Back on Avastin - try again!
8/26/13 Not ready to return to classroom yet :( But I CAN walk without holding onto things! :)
9/9/13 Brain MRI - fingers crossed
“ Life is a grindstone, and whether it grinds you down or polishes you up is for you, and you alone, to decide. ” – Cavett Robert
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Old 10-09-2011, 04:17 PM   #3
SoCalGal
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Re: Does cancer treatment age you?

IMHO entire ordeal is quite aging. Remedy - outlive your face.
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1996 cancer WTF?! 1.3 cm lumpectomy Er/Pr neg. Her2+ (20nodes NEGATIVE) did CMF + rads. NED.
2002 recurrence. Bilateral mastectomy w/TFL autologous recon. Then ACx2. Skin lymphatic rash. Taxotere w/Herceptin x4. Herceptin/Xeloda. Finally stops spreading.
2003 - Back to surgery, remove skin mets, and will have surgery one week later when pathology can confirm margins.
‘03 latisimus dorsi flap to remove skin mets. CLEAN MARGINS. Continue single agent Herceptin thru 4/04. NED.
‘04 '05 & 06 tiny recurrences - scar line. surgery to cut out. NED each time.
1/2006 Rads again, to scar line. NED.

3/07 Heartbreaking news - mets! lungs.sternum. Try Tykerb/Xeloda. Tykerb/Carbo/Gemzar. Switch Oncs.
12/07 Herceptin.Tykerb. Markers go stable.
2/8/08 gamma knife 13mm stupid brain met.
3/08 Herceptin/tykerb/avastin/zometa.
3/09 brain NED. Lungs STABLE.
4/09 attack sternum (10 daysPHOTONS.5 days ELECTRONS)
9/09 MARKERS normal!
3/10 PET/CT=manubrium intensely metabolically active but stable. NEDhead.
Wash out 5/10 for tdm1 but 6/10 CT STABLE, PET improving. Markers normal. Brain NED. Resume just Herceptin plus ZOMETA
Dec 2010 Brain NED, lungs/sternum stable. markers normal.
MAR 2011 stop Herceptin/allergy! Go back on Tykerb and switch to Xgeva.
May-Aug 2011 Tykerb Herceptin Xgeva.
Sept 2011 Tykerb, Herceptin, Zometa, Avastin.
April 2012 sketchy drug trial in NYC. 6 weeks later I’m NED!
OCT 2012 PET/CT shows a bunch of freakin’ progression. Back to LA and Herceptin.avastin.zometa.
12/20/12 add in PERJETA!
March 2013 – 5 YEARS POST continue HAPZ
APRIL 2013 - 6 yrs stage 4. "FAILED" PETscan on 4/2/13
May 2013: rePetted - improvement in lungs, left adrenal stable, right 6th rib inactive, (must be PERJETA avastin) sternum and L1 fruckin'worsen. Drop zometa. ADD Xgeva. Doc says get rads consultant for L1 and possible biopsy of L1. I say, no thanks, doc. Lets see what xgeva brings to the table first. It's summer.
June-August 2013HAPX Herceptin Avastin Perjeta xgeva.
Sept - now - on chemo hold for calming tummy we hope. Markers stable for 2 months.
Nov 2013 - Herceptin-Perjeta-Avastin-Xgeva (collageneous colitis, which explains tummy probs, added Entocort)
December '13 BRAIN MRI ned in da head.
Jan 2014: CONTINUING on HAPX…
FEB 2014 PetCT clinical “impression”: 1. newbie nodule - SUV 1.5 right apical nodule, mildly hypermetabolic “suggestive” of worsening neoplastic lesion. 2. moderate worsening of the sternum – SUV 5.6 from 3.8
3. increasing sclerosis & decreasing activity of L1 met “suggests” mild healing. (SUV 9.4 v 12.1 in May ‘13)
4. scattered lung nodules, up to 5mm in size = stable, no increased activity
5. other small scattered sclerotic lesions, one in right iliac and one in thoracic vertebral body similar in appearance to L1 without PET activity and not clearly pathologic
APRIL 2014 - 6 YRS POST GAMMA ZAP, 7 YRS MBC & 18 YEARS FROM ORIGINAL DX!
October 2014: hold avastin, continue HPX
Feb 2015 Cancer you lost. NEDHEAD 7 years post gamma zap miracle, 8 years ST4, +19 yrs original diagnosis.
Continue HPX. Adding back Avastin
Nov 2015 pet/ct is mixed result. L1 SUV is worse. Continue Herceptin/avastin/xgeva. Might revisit Perjeta for L1. Meantime going for rads consult for L1
December 2015 - brain stable. Continue Herceptin, Perjeta, Avastin and xgeva.
Jan 2016: 5 days, 20 grays, Rads to L1 and continue on HAPX. I’m trying to "save" TDM1 for next line. Hope the rads work to quiet L1. Sciatic pain extraordinaire :((
Markers drop post rads.
2/24/16 HAP plus X - markers are down
SCIATIC PAIN DEAL BREAKER.
3/23/16 Laminectomy w/coflex implant L4/5. NO MORE SCIATIC PAIN!!! Healing.
APRIL 2016 - 9 YRS MBC
July 2016 - continue HAP plus Xgeva.
DEC 2016 - PETCT: mets to sternum, lungs, L1 still about the same in size and PET activity. Markers not bad. Not making changes if I don't need to. Herceptin/Perjeta/Avastin/Xgeva
APRIL 2017 10 YEARS MBC
December 2017 - Progression - gonna switch it up
FEB 2018 - Kadcyla 3 cycles ---->progression :(
MAY30th - bronchoscopy, w/foundation1 - her2 enriched
Aug 27, 2018 - start clinical trial ZW25
JAN 2019 - ZW25 seems to be keeping me stable
APRIL 2019 - ONE DOZEN YEARS LIVING METASTATIC
MAY 2019 - progression back on herceptin add xeloda
JUNE 2019 - "6 mos average survival" LMD & CNS new single brain met - one zap during 5 days true beam SBRT to cord met
10/30/19 - stable brain and cord. progression lungs and bones. washing out. applying for ds8201a w nivolumab. hope they take me.
12/27/19 - begin ds8401a w nivolumab. after 2nd cycle nodes melt away. after 3rd cycle chest scan shows Improvement, brain MRI shows improvement, resolved areas & nothing new. switch to plain ENHERTU. after 4th cycle, PETscan shows mostly resolved or improved results. Markers near normal. I'm stunned but grateful.
10/26/20 - June 2021 Tucatinib/xeloda/herceptin - stable ish.
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Old 10-09-2011, 08:30 PM   #4
Catherine
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Re: Does cancer treatment age you?

I am 63 and 5.5 years out from DX. Luckily, I seem fine. In comparison to good friends my age, I do feel that I am aging faster than they are. But the good news is, I am aging.
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Found my own lump in the shower
April 2006 at the age of 58
Stage IIB, ER- PR- HER2+++ multi focal tumors, largest 2.3cm
Chemo first: AC/Taxol over 16 weeks
Bilateral mastectomy Sep 06
33 rads after the surgery
1 year of Herceptin completed Dec 07
15 years and no recurrence as of April 2021
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Old 10-09-2011, 08:42 PM   #5
ElaineM
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Wink Re: Does cancer treatment age you?

You got it right Catherine. At least we are aging and getting older. Yeah for us !!!!!!!!
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12 years and counting
http://her2support.org/vbulletin/showthread.php?t=48247
Lucky 13 !! I hope so !!!!!!
http://her2support.org/vbulletin/showthread.php?t=52807
14 Year Survivor
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"You never know how strong you are until being strong is the only choice you have." author unknown
Shared by a multiple myeloma survivor.
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Old 03-14-2012, 11:11 PM   #6
Rosanne
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Red face Re: Does cancer treatment age you?

I always wondered why I could not do things like people my own age. Yesterday I went to the optometrist thinking I might need a new prescription on my eyeglasses. Instead I was shocked to find out that at age 57 I am developing cataracts! My mother in her mid 80's just had cataract surgery! The doctor said it was from the cancer treatment. He said when the radiation kills the cancer cells it kills me too. I had breast cancer 3 times in 1998, 05 and 06, two lumpectomy's, radiation in 98 and 05, double mastectomy with lat flap reconstruction and oophrectomy in 06. I knew I had developed osteopenia after the cancer in 06 and knew I had bone spurs & degenerative arthritis in my spine so now it explains it. He said I would need cataract surgery in my mid to late 60's when most people are in their 70's so I realize even though I never had chemo I still aged 10 years and need to cut myself a little slack when I can't do what others do. I am still considered attractive and young looking for my age so they do not really understand how bad I feel a lot of the time. My sister died of breast cancer at age 46 even though it was detected as early as possible so I have to remind myself when I am getting on the pity pot and having a major feeling sorry for myself moment that I am still here. Besides the cancer I had so many other life problems but am determined to make it, exercise no matter how painful, eat right and be an example to my grown sons of how to keep going on when life gets so hard.
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Old 03-15-2012, 02:00 AM   #7
Jackie07
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Re: Does cancer treatment age you?

Hi,

I've actually got a younger-looking face after full-doses of chemotherapy in 2003 and 2007! I refer to them as my 'chemical peel'. A college classmate who visited me last year (our first reunion in almost 30 years) had commented how good I looked - no wrinkles/lines on my face whatsoever (thanks to the oily skin inherited from my father - see profile picture)!

People do think I'm old-looking, though. Mainly because I've had grey hair since my early 20's. But when I put on my wig and dress up, strangers seldom treat me as an 'old' lady.

Physically I'm still quite strong. One of my nieces helped take care of me early 2010 after my hysterectomy/oophorectomy. We took her to see the 'waterfall' at the end of the new walking/biking trail near our neighborhood. She fell asleep while sitting in the couch after coming back from the 15+15 minutes walk!
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7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
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Old 03-17-2012, 02:12 PM   #8
CoolBreeze
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Re: Does cancer treatment age you?

If you look at photos of me taken 3 years ago, right before dx, and ones now, you see a very different woman. Part of it is when my hair grew back, I didn't dye it, so now I have silver hair instead of red. But, a lot of it is sagging skin, wrinkles, and all the things menopause brings on.

I won't even mention the joint pain and aches. Estrogen is really important to us and it's too bad we can't supplement. It totally would.

I used to look ten years younger than my age. Now I look five years older. My little sister who didn't have cancer still looks ten years younger than her age. I'm afraid folks are going to think I'm her mother soon!
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08/17/09 Dx'd.
Multifocal/multicentric IDC, largest 3.4 cm, associated ADH, LCIS, DCIS
HER2+ ER+/PR- Grade 3, Node Negative

10/20/2009: Right mastectomy, reconstruction with TE
12/02/2009: Six rounds TCH, switched to Taxol halfway through due to neuropathy
03/31/2010: Finished chemo
05/01/2010: Began tamoxifen, the worst drug ever
11/18/2010: Reconstruction completed
12/02/2010: Finished herceptin
05/21/2011: Liver Mets. Quit Tamoxifen
06/22/2011: Navelbine/Zometa/Herceptin
10/03/2011: Liver Resection, left lobe. Microwave ablation, right lobe - going for cure!
11/26/2011: C-Diff Superbug Infection, "worst case doctor had seen in 20 years"
03/28/2012: Progression in ablated section of the liver - no more cure. Started Abraxane, continue herceptin/zometa
10/10/2012: Progression continues, started Halaven, along with herceptin and zometa.
01/15/2013: Progression continues, started Gemzar and Perjeta, an unusual combo, continuing with herceptin and zometa
03/13/2013: Quit Gemzar, body just won't handle it. Staying on herceptin, zometa and perjeta.
04/03/2013: CT shows 50% regression in tumor, so am starting back on Gemzar with dose reduction, staying with perjeta/herceptin/zometa. Can't argue with success!
05/09/2013: Discussing SBRT with Radiology due to inability of bone marrow to recover from chemo.
06/07/2013: Fiducial placement for SBRT
07/03/2013: Chemo discontinued, on Perjeta, Herceptin and Zometa alone
07/25/2013: SBRT (gamma knife) begins
08/01/2013: SBRT completed
08/15/2013: STABLE! continuing with Perjeta, Herceptin, Zometa
06/18/2014: ***** NED!!!!***** continuing with Perjeta, Herceptin, Zometa
01/29/2014: Still NED. continuing with Perjeta, Herceptin. Zometa lowered to every 3 months instead of monthly.
11/08/2015: Progression throughout abdomen and lungs. Started TDM-1, aka Kadcyla. Other meds discontinued. Remission was nice while it lasted.

5/27/18: Stable. Kadcyla put me right back in the barn. I have two teeny spots on my lungs that are metabolically inactive, and liver is clean.

I’m beating this MFer. I was 51 when this started and had two kids, 22 and 12. Now I’m 60. My oldest got married and trying to start s family. My youngesg graduates from Caltech this June. My stepdaughter gave me grandkids. Life is fantastic.
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Old 03-17-2012, 04:05 PM   #9
tricia keegan
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Re: Does cancer treatment age you?

I also feel I have aged so much!
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Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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Old 03-17-2012, 06:44 PM   #10
mimiflower07
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Re: Does cancer treatment age you?

Boy can I relate, we really need estrogen my face is falling down and other parts r drying up! 41/2 yrs out and I'm thinking" show me the Botox "
Lol...Suzanne
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dx aug10/07
3 pos high, grade 3
tumor 2.5cm multifoc
bil mast recon sept 24/07
neg snb/neg lymph vascular
clear marg
chemo a/cx 4 rds
tomoxifan started feb11/08
herceptin to begin soon
herceptin completed feb/09
aromacin(A.I)for as long as i can
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Old 03-18-2012, 10:21 AM   #11
AlaskaAngel
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Question Re: Does cancer treatment age you?

The numbers tell us that 2/3 of all breast cancers happen to people over age 55. The spread is slightly younger for those who are HER2 positive but still most are being hit with it at middle age.

We do the best we can. But I think a much better job of it could be done by us and our providers. Breast cancer and treatment have been around for decades, and without truthful information right up front about what we are likely to face, the process is a lot more difficult and painful than it needs to be.

Sometimes it gets hidden behind the excuse that it is okay not to be honest with patients ahead of time because "maybe they won't do what providers think is best". Sometimes it happens just because the nurses who see us haven't had the experience themselves and at 20 or 30 or even 40 they still do have more ability to exercise while eating more, where we don't. The worst among them are the providers who can dole out the treatment and pass out the post-treatment meds and lubricants, but don't provide realistic counseling about aging and sexual changes that come with treatment.

And some of it is the differences among us in age at time of treatment. There are those who are still young and "lucky" because they are on "temporary menopause" through drugs that cause temporary cessation of menstruation -- but at the same time, remain at higher risk for recurrence because they are younger. Unfortunately they often post about how quickly they recovered from treatment, and how easy it was to lose the weight they gained during treatment, and how their hair came back very nicely, as if that is what happens with most cancer patients (and as if most other cancer patients just like to complain more, or aren't trying as hard).

Is it that hard to be truthful about treatment with patients so that they don't end up feeling like they were too stupid to know they were being misled?

AlaskaAngel
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Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
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Old 03-18-2012, 12:43 PM   #12
chrisy
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Re: Does cancer treatment age you?

Well, yes, all of that. Sometimes, and in some ways I feel all the treatment has "aged" me. Certainly tipped me quickly into menopause and thus has cheated me out of a lot. Sometimes I have marveled at how well I felt, how good I looked compared to those around me of the same "age".

On the other hand,

HOWEVER....
In my case, I know that while treatments may have aged me, they have also allowed me to continue aging. So for now, that's a good thing.

My hope is that better treatments will enable me to continue to age (somewhat) gracefully, until I am aged to perfection.
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 03-21-2012, 05:29 PM   #13
Carol.hope
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Re: Does cancer treatment age you?

Studies published in 2001-2006 show that chemo shortens telomeres, which are the ends of our DNA strands. They are responsible for replicating and making new cells, which is what keeps us young. As we age, they are less able to make new cells, so we are left with our old cells. A study published in Clinical Cancer Research in 2006 showed that 8 weeks of cisplatin reduced telomere length the equivalent of 22 years of natural aging! Just imagine the impacts to those of us who had A/C and Taxol (before our favorite, Herceptin). I think we look pretty good for being at least22 years older than our calendar age!

It's the steroids that cause cataracts. I had both lenses replaced a year after chemo, and was so pleased to have better vision! That's what we get from cancer and chemo - a whole new look at life!

Carol
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Lyons, CO

dx June '05 at age 55
Stage 1, 1.5cm
ER+++, PR--, HER2+++
Lumpectomy, A/C, T/H
Herceptin stopped due to low LVEF (35%)
2010: NED, but continuing major chemo brain injury
www.BeyondChemoBrain.com
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Old 03-21-2012, 08:23 PM   #14
Henny
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Re: Does cancer treatment age you?

I took a health assessment from my husband's health insurance company. Even with my exercising, eating right, no smoking, and hardly ever drinking I came out as 7 years older than my 59 years. Boy was I pissed off about that. I retook the test and dropped the part about having cancer and treatment and the program said I have the body of someone 8 years younger.

My conclusion is that you're only as old as you feel and right now I feel great (tho tomorrow morning after a class at the gym I may feel 90!)
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Dx 3/07 IDC and DCIS Her2+ ER- PR-
Stage IIb 1/15 nodes
A/C, Taxol, Herceptin
Bilateral mastectomies with recon
Zometa 2/yr for 3 yrs- finished 8/2011
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Old 03-22-2012, 06:19 AM   #15
Firework
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Re: Does cancer treatment age you?

The treatment following the cancer has taken my sexy away.......I've lost my waist and for the first time in my life have belly fat.Have gained up to 15 pounds since treatment, have brought it down to 10 lbs over my usual. I went into an early menopause, (36) so it shouldn't just be the addition of Arimidex. The bone/joint pain with Nuelasta was terrible for me, unfortunately I have joint pain from Arimidex. I'm turning 50 and have been pretty dry for a number of years..aagh. All in all I would say cancer has doubled my aging years.
On the upside......my sexy is in my head so that can come back with an attitude and perception adjustment.
I'll keep exercising....water aerobics, walking, free weights so at least my new jiggle has to compete with stronger muscle mass.
And for the dryness......has anyone ever tried motor oil?!!!!!!
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Dx'd 5/2011 IDC 1.6cm, stage 1, grade 2, er+pr-, HER 2, 0/2 nodes, P53 75%, KI67 90%
6/23 bilat mast, port 6/27 expanders, 8/08 AC x6, Herceptin 1 yr., Arimidex -Jan 1st 2012- 5 years, reconstruction- exchange surgery 3/30, nipples 7/2012? Then tattoos......
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