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Old 09-23-2005, 03:04 AM   #1
Christine MH
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Her2 BC in Mice Eradicated Using Vaccine

http://www.upenn.edu/researchatpenn/article.php?979&hlt
Breast Tumors in Mice Eradicated Using Cancer Vaccine

From the University of Pennsyvania Press Release:
September 15, 2005

By: Karen Kreeger

A team from the University of Pennsylvania School of Medicine has shown that by using a cancer vaccine based on the bacterium Listeria monocytogenes, they can cure mice with established breast tumors. Cancer vaccines, which are more properly described as immunotherapy, work by boosting an immune response against tumor-associated antigens. Using Listeria, the researchers, led by Yvonne Paterson, PhD, Professor of Microbiology, delivered the tumor-associated antigen HER-2/Neu to immune cells. HER-2/Neu is overexpressed in 20 to 40 percent of all breast cancers and also present in many cancers of the ovaries, lung, pancreas, and gastrointestinal tract. These cells eventually enlist killer T cells to seek out and destroy the tumor cells that display the HER-2/Neu molecule.

'We found that we can stop the tumor from growing out to 100 days, at which time we stopped measuring since this is a long time for experiments of this type,' says Paterson. 'The tumors stopped growing or went completely away.' The researchers published their findings in the September 15 issue of the Journal of Immunology."

The whole thing, including the scientific explanation of how it works, is available at the URL above.
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