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Old 02-27-2008, 01:26 AM   #1
Faith in Him
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Sleepness nights after chemo

I had chemo today so I am unable to sleep. I think the pre-meds are to blame. Has anyone who has had this problem taken meds to help them sleep on chemo days?

I only have vacodine and Xanax in the house and I don't know if these would work.

Thanks,
Tonya
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DX 02/01/07
2.5 cm, Er/Pr-, Her2+++
18/20 Nodes
03/07 CT & Bone scan - Clear
AC x 4, Taxol x 4, Added Herceptin
Radiation until 09/07
Herceptin every 3 weeks until 06/08
01/10/08 local recurrence -IBC
01/28/08 CT & Brain MRI - clear
02/08 - Navelbine & Herceptin
05/08 -MRM
05/08 - Gemzar & Herceptin - didn't work
09/08 - Hyperthermia rads
03/09 - Tykerb/Xeloda
05/10 - Tram flap to fix wound
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Old 02-27-2008, 05:16 AM   #2
Sheila
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Tonya
What premeds are you getting...chances are, if you are getting a steroid, you feel wired for a couple days....mine hits the night of chemo, and lasts for 3-4 days straight, the I get it out of my system. My Dr ordered Ambien, although i rarely take it...just don't want to do the sleeping pill thing...some have had great luck with Lunesta, also a prescription. Start by taking a Xanax, and see if it helps...the Vicodin will make you sleepy usually, but is more for pain...just don't mix the 2 or mix with alcohol.....hope this helps, sweet dreams
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Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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Old 02-27-2008, 07:27 AM   #3
PinkGirl
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Hi Faith
I had this problem too. The first
night was the worst one. My chemo
nurse suggested taking an Ativan at
bedtime - it did help me sleep but my
husband told me that my arms and legs
moved all night - like I was running a
marathon. I am careful with the Ativan
and only took it for the first few nights
after a treatment.

Hope you find something that helps. You
need your sleep. Good luck with this.
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Dx Aug/05 at age 51
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Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
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Arimidex for 5 years
Prophylactic mastectomy June 22/09



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Old 02-27-2008, 08:14 AM   #4
MJo
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I stayed awake many nights during chemo. I'm sure the premeds had something to do with it, but I also think chemo turns our bodies inside out and upside down. Any positives? There are some great movies on at 3 a.m.
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IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
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Old 02-27-2008, 09:44 AM   #5
Carol Carlson
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I'm a bit of an insomniac anyway, so when I was on chemo, my Dr. gave me Ambien which worked well. Her feeling was that " you need your sleep" while going through chemo. A good night's sleep is important and helps you heal .But like anything , else, moderation and common sense is key. I stopped taking it after chemo but still have a prescription for it and if I have a particularly difficult night sleepng, I'll take one.
Talk to your doctor about it. They all differ as to their opinions re: taking something for sleep. Some hand them out like M&M's while others are overly cautious about the risk of addiction.
Mine is kind of common sense about it and so am I. Use it but don't abuse it I guess is good advice.
Good luck.
Carol C.
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Old 02-27-2008, 10:07 AM   #6
Emelie
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I took Ambien after a minor surgical procedure and used it during chemo. It worked great for me. I only take it now if I haven't slept for several days in a row due to hot flashes, and stress.
Talk to your doctor and let them know you are having difficulty sleeping. I am sure they can help you with this problem
Good luck,
Emelie
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Old 02-27-2008, 01:55 PM   #7
TSund
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Perhaps Benadryl at bedtime? Since this often given with chemo should not hurt.

Melatonin will help a little and is a good supplement for bc.

Also...if you are not experiencing nausea, etc. you could ask that the steroid doasage be cut back. Ruth did so, and things were much better.

TRS
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Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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Old 02-27-2008, 01:58 PM   #8
Chelee
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Tonya, Those pre-meds will keep you wired up a bit for a couple days. So yes...the problem of sleeping is very common while going through chemo. Sleep is important so I would try your xanax first...that should help. If not *most* onc's are good about making sure you have something to help you sleep. So if the xanax doesn't work ask your onc about it. Many like the Ambiem but for me that didn't work at all. Ambiem is really to help you fall asleep...but not keep you asleep. Actually there is a newer version of Ambiem so it might be better then what I tried.

The xanax and Ativan worked the best for me. But you will want to try something because its bad enough going through chemo without having to worry about not getting any sleep. Again...this is a very common problem so tell your onc if the xanax doesn't do it. Hang in there.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 02-27-2008, 06:18 PM   #9
Lolly
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I takd 2 mg of melatonin and 25 mg of benedryl about an hour before bedtime. It usually works pretty well, even on chemo nights after pre-meds which for me include steroids. Check with your onc first.

<3 Lolly
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.

Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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Old 02-27-2008, 06:36 PM   #10
Bill
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Wink

Hi Tonya, i know the not sleeping thing can be miserable. You've already gotten alot of great advice from the sisters. I think trying to reduce the premed steroid a little might help. Just a couple thoughts from me. I don't know what your routine is after chemo., and I know you have young children, but maybe, on chemo nights, if you don't already, you could just slip into a nice, hot bath, with fragrant candles lit and nice soft music playing, and after your bath, take an Ambien or melatonin tablet with a soothing cup of herbal tea and slip right into bed (Maybe preheated with an electric blanket) Your husband seems like a wonderful man. Perhaps on chemo. night, if it works for you and your family, it could be "pizza and movie night" or whatever, for him and the kids while you relax. I have sleep apnea, and we used to let our Rottweiler, Wyatt, sleep in our bedroom, and he would bang around all night, and once I went to sleep and then "got woke up" I had a terrible time going back to sleep. If this is similar to your situation, maybe your husband could "camp out" with the kids in the living room and give you more quiet time in the bedroom as you try to relax. Uh oh, please don't think I'm comparing your husband to a big dog, because I'm not, I just meant if you have the room to yourself and go through a relaxation process, you might be able to relax and stay asleep better. Nikki used to play a CD of "ocean music" set to replay over and over of waves crashing on the beach, gulls, etc. and it was soothing and relaxing. Also, if changing your day of treatment might help, consider that. Love and prayers to you, Bill
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Old 03-02-2008, 12:37 AM   #11
harrie
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The premed decadron made sleeping difficult for me. Benedryl helped or else a night-time sleep aid (OTC) such as Sominex (the active ingredient is the same as Benedryl).
Maryanne
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*** MARYANNE *** aka HARRIECANARIE

1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen

2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy

2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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Old 03-03-2008, 01:03 AM   #12
weezie1053
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I worked during my chemo, and it was hard enough to function with chemo brain, but no sleep was even tougher. I followed the advise of many of these ladies and decided quality of life would improve a sleep aid. My Onc prescribed Ambien, and it worked like a charm. I often broke it in half.

Good Luck

Louise
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  • Diagnosis 06/06 - Stage II-A BC; BC was 2.5 cm, grade 2; ER/PR negative & HER-2/neu positive;
  • Mastectomy w/ reconstruction (implant) in 09/06;lymph nodes - negative;
  • AC/Cytoxin combo - 4 treatments (dose dense);
  • Taxol/Herceptin combo- 12 weekly treatments;
  • Completed chemo - 2/07; completed restruction 02/07; reduction of left breast.
  • BRCA 1 and 2 negative - 6/15/07;DX high risk for distant recurrence
  • MRI, 08/02/07 - NED
  • 1 year Anniversary - 09/07; completed Herceptin 11/07.
  • Mammo 02/14/08 - NED; MRI - 08/2008 - NED
  • 2 year Anniversary - 09/08
  • Mammo 02/09 - NED; MRI - 08/09 - NED
  • 3rd year Anniversary - 09/09
  • 5th Annivery - 09/2011 - NED
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Old 03-03-2008, 06:06 AM   #13
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Tonya,

It is quite normal not to be able to sleep for a day or two following chemo. It's from the steroid (usually decadron) that is given as a premed. Don't be afraid to ask your doctor for something to help you sleep. I have tried Lunesta, Ambien and Rozeram. I found that the AmbienCR worked the best. It not only let you get to sleep it actually gave me a good night's sleep. I still use it on occasion -- you know the nights when the mind just won't shut down.
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Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 03-03-2008, 06:07 AM   #14
goops
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I had the trouble when I was on A/C - I told the chemo nurses and they prescribed a anti-nausea drug that also made you sleepy. I only used it at night. I cannot remember the name of the drug, but if you your oncologist they could likely give you something similar.

When I started to take tomixifen I had trouble sleeping because of the hot flashes. Melatonin has helped me sleep better.
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Old 10-28-2018, 12:05 PM   #15
donocco
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Re: Sleepness nights after chemo

The name of the anti-nausea drug that causes drowsiness probably was Ativan, generic name Lorazepam.
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Old 10-31-2018, 08:49 AM   #16
jaykay
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Re: Sleepness nights after chemo

I believe the drug is zofran for nausea. Ativan for stress relief, sleeping aid. Similar to Valium
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March, 2000: 48, Post menopausal (5 yrs HRT) Left breast, IDC 3mm/DCIS 1.6cm, ER+/PR-/Her2+++, mod differentiated, MIB low, lumpectomy, node neg via SNB, rads=33 Stage 1a
June, 2000: Tamox 4.5 years,Femara for 5 years (end in Jan. 2010)
Sept, 2012: 61, Via mamm, ultrasound, biopsy, right breast, 2.3cm tumor, ER+/PR-/Her2+++, poorly diff, KI67 60-70%
BRCA 1 and 2 negative
October, 2012: Bi Mast with tissue expanders, port placement
Final Path: IDC 2.8cm, DCIS, 1/4 sentinal nodes positive (@#$%). Stage IIB
Nov 29, 2012: Begin TCH/6x/every 3 wks, H for 1 year/every 3 weeks.
March 14, 2013: Finished chemo
April 9, 2013: Begin radiation 28x
May 22, 2013: Finished rads
June 1st, 2013: Started Aromasin for 5 yrs.
July 15, 2013: Switched to Letrozole (Femara). Probably for the rest of my life
October 16, 2013: Exchange surgery
October 31, 2013: Finished Herceptin
December 5, 2013: Port removed
Glad this year is over!
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Old 10-31-2018, 10:33 AM   #17
donocco
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Re: Sleepness nights after chemo

You are correct that Ativan is technically not an anti-nausea drug. Some cases of nausea and vomiting are partly psychological. The patient remembers past nausea and vomiting and
anticipates the next round. Mind can be stronger than body sometimes. Even if they are premedicated with say Zofran or Kytril they still feel nausea with the chemo. Yes Ativan is very much like Valium. They both belong to a class of chemicals called Benzodiazepines. This class includes Xanax, Dalmane, Klonopin etc etc
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Old 11-01-2018, 01:18 PM   #18
Lucy
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Re: Sleepness nights after chemo

I had no problems sleeping when on chemo and getting steroids. In fact I had problems staying awake. I was sleeping 16-20 hours a day. I wonder if there's a difference in dose or brand of drugs from when this thread was started to now? This thread was started ten years ago and I was on chemo in 2014.
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Old 11-05-2018, 05:23 AM   #19
JessicaV
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Re: Sleepness nights after chemo

I was on chemo in 2014. I found the steroid premed my oncologist prescribed (Methasone) had me wired from the day before my chemo until the day after it. Then I slowly sank down into exhaustion and misery. So I used that high-energy to make a fun picnic to take with me to chemo and share with my daughter who came with me, and prepared myself for the total low point of despair I knew was coming two days later. Sleep was often a problem for the first 8-10 days. I remember bad nights meant watching each hour on the clock from 9pm to 8am, and I was so grateful to have good books to get me through. After that, I would start to feel normal and know I was about to go through it all again.
I celebrate the courage of every one of us who gets herself through this challenging process out of determination to stay alive a bit longer against all odds.
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1997-2004 many cysts, many MG & U/S: polycystic breasts.
Sept 2013 found lump,Cyst?? forgot lump.
Dec 2013 GP check, Referred for U/S, MG,FNA.
7 Jan 2014 Radiology: Radiologist turned screen away from me. When asked she said "Not a cyst, very suspicious.See your GP asa results avail."
Cancelled my psych clients for the week.
8 Jan 14 GP: 2.2cm IDC in 6cm DCIS field. FNA=malignant cells. Referred to Surgeon.
Cancelled my psych clients for the month.
13 Jan
14 Surgeon said L mastectomy not lumpectomy, offered neoadjunctive trial, agreed adjunctive chemo after surgery a good choice for me. Booked Body scan and bone scan for staging (both fine) Surgery for16 Jan,
16 Jan 14 Surgeon also agreed in preop meeting to also remove 6cm fatty cyst in job lot. Good job done.
19 Jan 14 discharged home with 1 drain.
22 Jan 14 drain partly pulled out overnight, serious seroma (600 ml reducing removed every 2 days for a month) Serious staph infection because nurse said wait 3 days for yr surgeon appointment.
26Jan 14 pathology: 2.2cm Grade 3(3,3,2)ER-, PgR-, HER2+2 so to be confirmed by Sish test. Node negative. No vascular or lymphatic involvement. No metastases in scans.
30 Jan 14 HER2+ high amplification, 13 gene copies per cell.
21st Feb 14 Began 3wkly TCH adjuvant treatment at The Mount Hospital Perth, with 3monthly MUGA heart tests +Oncologist or Surgeon full physical check-up.
Cancelled my psych clients for 6 months.
Feb 14 First MUGA test: 71%,
First C15.3 test: 20
7th March 14 began Neulasta self-applied injections 24hrs after each TCH treatment. Bonepain helped by spa, heatpacks and
Claritin, reflux/indigestion helped by Somac.
July 14 completed docetaxol and carboplatin, ongoing herceptin to 12 months. Severe cognitive deficit/fatigue after 1pm daily.
Sept 14 Second MUGA test: 69%
Cancelled my psych clients for 2014
Dec 14 Third MUGA test: 70%
Second C15.3 test : 20
Cognitive fatigue delays return to work.

March 2015 Tachycardia pulse 168, night in hospital. Cardiologist says no heart disease, ALIVE ECG attachment for my mobile phone now regular monitoring.
July 2015 Worktrial, up to 8hrs per wk. Fatigue ongoing
Aug 2015 Heart good, no evidence of cancer, just Fatigue.
May 2019 Melanoma 1.5cm Stage 1 by right collarbone(was present as large freckle in 2014 and cut through by breast surgeon to remove fatty cyst at same time as mastectomy.) Melanoma removed leaving scar from shoulder to breastbone. In hospital twice for IV antibiotics. Told catagorically this could not be BC mets.
Dec 2019 Still NED, still fatigue in late afternoon, but have my brain back in the early mornings. So most days I watch the sunrise and hear the birds morning chorus in my bush backyard and am glad to be alive and to be me still.

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