elevated liver enzymes

robint · 04-28-2008, 07:57 PM

does any one know what they could mean? I am on tykerb and herceptin,
stopped tykerb for 2 weeks canceled herceptin for they are trending up. i have a right upper quadrant ache. ultra sound negative gallbladder. they are redoing blood work in 2 weeks and CT.

Becky · 04-29-2008, 05:59 PM

Dear Robin

Markers can mean anything. What matters most is if they have ever meant anything to you in the past? Do or did you have liver mets? Right upper quadrant pain can point to the liver or the ribs or just aches and pains of treatment. Many of us have had this kind of pain but it was nothing after a scan. The most important thing is to make sure you get it checked out and it seems that you are. I am sorry you have some aching as it is just as scary whether it is something or not. You will know soon and if you can't stand the waiting, call your onc so the scan can get moved up.

Make sure to let us know how you are doing and don't be afraid to post if you need support. We are here for you.

Julie2 · 04-30-2008, 09:16 AM

Dear Robin,

Are you just on Herceptin and Tykerib? I heard for somebody liver enzymes going up with Tykerib. Where is your decease located?

Thanks,
Julie

robint · 05-02-2008, 09:21 PM

I am er-,pr- and her2/neu positive 3+++. grade 3, IDC and extensive dcis
double masc 6/2007. 8/2007 started AC 4, Taxol, herceptin, tykerb 12 weekly,
herceptin and tykerb i have 24 weeks left. I have right upper quadrant pain and feel bloated this started 6 weeks ago had ultrasound to see if it was gall bladder. the results were negative, enzymes are remaining high. scheduled for ct and blood work on teusday.I have been off tykerb for 2 weeks and I did not recieve herceptin this last scheduled time monday. they tested me for hepatitis a little scary-totally negative. waiting for ct- hoping its not mets

I had severe neutropenia,and appendectomy between AC and Taxol.

Jackie07 · 05-03-2008, 03:33 PM

I hope more people will answer your question about liver enzymes.

05-10-2008, 11:12 PM

I had them and I had a PET that was neg. and I had a liver biopsy that showed "fatty liver". I having the liver cleared I was okayed to have my bilateral breast reconstruction with abdominoplasty (TRAM). My gastroentologist but me on Acticall, lecithin and Vit. E. I have only been taking it for one month, and I'm anxious to get my liver enzymes redone. Currently I am taking Herceptin IV every three weeks. I also am unable to loose weight. Please let me know what you find out. Thanks

Mary Anne in TX · 05-11-2008, 06:06 AM

Robin, I don't have experience with what you are dealing with, but would sure like to hear how you are doing! ma

robint · 05-12-2008, 02:04 PM

had ct scan last week negative, liver enzymes went up 30 points. spoke with onc on friday. referred me to Gastoenterologist, saw him today had more bloodwork scheduled for a hida scan and endoscopy wedneseday and thursday, if negative then a liver biopsys next week. Thank you for your replies and concern.

Lori R · 05-12-2008, 04:57 PM

Robin,
I replied to another thread of yours as another liver enzyme watcher.

I am very pleased that your Drs are performing tests to make sure that they figure the trend out.

I too had elevated liver enzymes coming off of 6 rounds of Taxotere + Herceptin. It seemed odd that while I was on all of the super strength drugs that the enzymes were fine. But...they rose by about 30 points 2 months after the chemo completion. This lasted for 2 rounds of testing. Not certain why, but they recently settled themselves down.

What is a hidascan?

Please don't fret too much if you have to have a liver biopsy. When then told me I was going to have one early in this journey it sounded HORRIBLE. Maybe I still still in a shock but I did not find the procedure to be too painful. It sounds worse than it is.

I am certainly behind you..cheering you on....Lori

ElaineM · 06-02-2008, 10:41 AM

Hi,
I had elevated liver enzymes the first time I took Adrainmycin and Taxotere in 2000, but they went back to normal after one or two weeks. I would speak up and check it out though. Better to be safe than sorry.

robint · 06-03-2008, 06:42 AM

all the test have been negative to date, Enzymes still high, alk phos, alt,ast,now billirubin is elevated slightly, testing every week and going up about 30 points each time no drugs for 6 weeks. frustrated for we are at to possibilities, toxic liver that may have damaged a portion and continuing to progress or mets that are not obvious on ct. I cannot have mri, for expanders
i think we will repeat ultra sound. we are waiting to see if they will trend down, then schedule biopsys.

thanks

Gina · 06-18-2008, 09:21 AM

Very interested to know how you are doing now. Have your doctors checked to see if your bile duct is being blocked by a stone or is inflamed with bacterial infection?

Not to worry, if it is the bile duct, they will put in a stent and you will be FINE and all the liver enzymes will normalize and the Alk phos and the bilirubin will go down. However, get on it, as if you don't --the bilirubin will build and you will turn yellow all over and risk liver failure if your liver enzymes approach 800 ALERT...

fyi,
Gina
Gpopp@Comcast.net