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Old 08-06-2019, 08:21 AM   #1
Nguyen
Senior Member
 
Join Date: Nov 2005
Posts: 228
Why mouse models fail.

Well, I am not sure if you are interested in these articles, but I often wonder the detail of why mouse model fail so often, less than 8% of models translated to clinical trial. Essentially there are a couple of reasons, differences in immune systems, genes expressions, and in tumor mutation paths. Hum, thatís practically everything! But in case you are bored, here they are:

https://www.ncbi.nlm.nih.gov/pmc/art...r0006-0114.pdf

https://www.ncbi.nlm.nih.gov/pmc/art...ihms906208.pdf

https://www.the-scientist.com/news-o...-humans--66223

https://www.npr.org/sections/health-...ried-in-people

Nguyen
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