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Old 05-17-2007, 06:28 AM   #1
Hopeful
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Join Date: Aug 2006
Posts: 3,380
Meta Analysis of Ki-67

http://www.breastcancersource.com/br..._27059___.aspx

Hopeful
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Old 06-03-2007, 08:40 PM   #2
Jean
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Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
Hopful,

Very interesting article, when I saw Dr. Slamon last April we discussed Ki-67 levels and he told then that this was a very important aspect of the tumor
and that the level and the fact of having a postive Ki-67 was extremely important and that my dr. in New York had missed the boat in not addressing
this aspect of my tumor.

Interesting, thanks for posting this article.

Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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Old 06-04-2007, 03:12 AM   #3
R.B.
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Posts: 1,843
Less omega six + more omega three = less Ki-67



RB


http://www.leaonline.com/doi/abs/10....journalCode=nc

Tumor prostaglandin E2 concentrations were reduced by feeding the lower LA level; further dose-dependent decreases occurred in the DHA dietary groups and were accompanied by reduced levels of 12- and 15-hydroxyeicosatetraenoic acids. These changes in eicosanoid biosynthesis may have been responsible for the observed decreases in cell proliferation, indicated by suppressed Ki-67 expression, and increases in apoptotic activity, as reflected in TdT-mediated dUTP nick end labeling immunohistochemical staining.
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