More Than 400 Antibody Based Drugs in Development

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http://www.therapeuticsdaily.com/new...e&channelID=28
There Are Currently More Than 400 Antibody Based Drugs in Development for the Treatment of Cancer

DUBLIN, Ireland--(BUSINESS WIRE)--Jun 15, 2007 - Research and Markets (http://www.researchandmarkets.com/reports/c59818) has announced the addition of "Antibody Drug Target Atlas in Oncology" to their offering.

The elaborate advances towards the blueprinting of the altered molecular networks that lie behind cancer development have paved the way for targeted therapy in cancer. There are currently more than 400 antibody based drugs in development for the treatment of cancer. What and where they are targeting has to date only been a fragmented knowledge. First in place, we have surveyed these antibodies and identified 132 antibody drug targets, belonging to 220 antibody drugs. In all they range from preclinical development to established therapy leaders in the market place. Drug targets and their associated antibodies have been analyzed according to: -0-
- 34 Different molecular functions of target
- 13 Major signalling pathways
- Cancer stem cells
- Conjugated antibodies
- Therapeutic effects: Anti-angiogenesis, Apoptosis and Protein Kinase
Inhibition
- 31 Targeted cancer indications
- Availability of expression profiles of targets in human tissues,
cancer tissues, established cell lines and primary cell cultures
- Antibody therapeutic companies

Single target analysis of the 132 antibody targets is performed, including targeted cancer indications, antibody drugs involved and their developmental stages. In total more than 420 clinical trials are included in this analysis, covering more than 30 different cancer indications plus diagnosis and supportive care.
This report serves as a serious reference for professionals interested in the development of oncology drug targets and selection/validation of targeting strategies. -0-
Topics:
- Antibody Drug Target Analysis in Oncology: What and Where Are We
Targeting?
- Antibody Drug Targets by Molecular Function
- Antibody Drugs Targeting Signalling Pathways
- Antibodies Targeting Cancer Stem Cells
- Targets of Antibody Conjugates
- Antibody Drug Targets by Three Major Non Immunological Therapeutic
Effects
- Antibody Targets and Drugs by Cancer Indications
- Expression Profiles of Antibody Drug Targets
- Disclaimer
- Drug Index
- Company Index
- Appendix I: Antibody Targets by Companies

For more information visit http://www.researchandmarkets.com/reports/c59818.
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Laura Wood, Senior Manager
Fax: +353 1 4100 980
press@researchandmarkets.com