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Old 04-02-2014, 02:48 PM   #1
Nguyen
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how do PTEN, Ki67, and IGFR1 affect treatment?

Hello,

Does anyone happen to know how does Pten, Ki67, or IGFR1 affect treatment selection?

Many thanks,

Nguyen
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Old 04-03-2014, 12:31 AM   #2
Jackie07
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Re: how do PTEN, Ki67, and IGFR1 affect treatment?

Hi Nguyen,

Hope the abstract below helps:

World J Surg Oncol. 2013 Nov 30;11:307. doi: 10.1186/1477-7819-11-307.
Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy.
Huang L1, Chen T, Chen C, Chen S, Liu Y, Wu J, Shao Z.
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Abstract
BACKGROUND:
To evaluate the predictive and prognostic value of various molecular factors associated with the Ras/MAPK and PI3K/Akt signaling pathways in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy (NAC).
METHODS:
A total of 113 patients were recruited in this retrospective study. Core needle biopsies and excision samples were assessed through immunohistochemistry for various biomarkers, including IGF-1R, Phospho-p44/42, Ki67, pAKT, PTEN, p27, and cyclinD1. The changes in these biomarkers after NAC and their predictive and prognostic values were investigated.
RESULTS:
Significant decreases in Ki67, Phospho-p44/42, and pAKT expression were observed after treatment (30.7% vs. 18.1%, 36.4% vs. 18.9%, and 35.1% vs. 16.4%, respectively). The decreases in Phospho-p44/42, pAKT, and Ki67 expression were strongly associated with the response to anthracycline treatment (P = 0.027, P = 0.031, and P = 0.008, respectively). In a multivariate survival analysis, Phospho-p44/42 expression after neoadjuvant chemotherapy and lymph node status were significant independent prognostic factors of both relapse-free survival and overall survival.
CONCLUSIONS:
Reductions in Ki-67, Phospho-p44/42, and pAKT expression are related to the clinical response to anthracycline-based NAC in HER2-positive breast cancer patients. High pAKT expression prior to NAC had a better clinical response. Phospho-p44/42 expression and lymph node status after NAC could be useful for determining relapse-free survival and overall survival.
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