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Old 02-09-2012, 11:40 PM   #1
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,778
new discovery on how IBC evades immune system

hopefully will lead to new treatments:

Public release date: 9-Feb-2012


Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Metastatic breast cancer hitches a free ride from the immune system

Inflammatory breast cancer (IBC) is the most lethal form of breast cancer . It spreads easily through the lymphatic and blood vessels, forming metastasis which can lead to multi-organ failure. New research published in BioMed Central's open access journal Cell Communication and Signaling demonstrates how IBC cells use IL-8, secreted as part of the anti-inflammatory response by a specific set of white blood cells (monocytes), to increase fibronectin expression.

Fibronectin is a cell-adhesion molecule which is usually involved in wound healing and cell migration during embryogenesis. Over-expression of this molecule is thought to allow cancer to metastasize. Prof Mona Mohamed from Cairo University used a cytokine antibody array to identify which immune-regulating molecules (cytokines, chemokines, and growth factors) were secreted by monocytes and found that, while monocytes secreted a small amount each of a wide range of molecules, there was up to 10 times more IL-8 and MCP-1.

The cocktail of immune-regulating molecules from the monocytes was able to increase the amount of fibronectin produced in IBC cells and in 3D culture produced branch-like structures typical of fibronectin over-expression. IL-8 on its own also turned up fibronectin expression in IBC cells. Prof Mohamed explained, "Adding IL-8 on its own to IBC cells caused an increase in the signaling proteins PI3K and AKT and it is this pathway which is responsible for fibronectin production."

The monocyte cocktail did not alter expression of another cell adhesion molecule, E-cadherin. Prof Mohamed continued, "From what we already knew about cell adhesion and these results, it seems that IBC cells are held together in clumps by E-cadherin, but fibronectin, and the IL-8 signaling pathway, are involved in branching and invasion necessary for metastasis of IBC."

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Notes to Editors

1. Monocytes conditioned media stimulate fibronectin expression and spreading of inflammatory breast cancer cells in three-dimensional culture: A mechanism mediated by IL-8 signaling pathway
Mona M Mohamed
Cell Communication and Signaling (in press)

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request at press@biomedcentral.com on the day of publication.

2. Cell Communication and Signaling, the official journal of the Signal Transduction Society, is an open access, peer-reviewed, online journal that encompasses all basic and translational aspects of cellular communications and signaling pathways in normal and pathological conditions.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.
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