HonCode

Go Back   HER2 Support Group Forums > Breast Cancer News
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 05-22-2013, 02:50 PM   #1
1rarebird
Senior Member
 
Join Date: Feb 2010
Location: TN
Posts: 175
Dimentia not linked Tamoxifen or ER therapy--good news

I like it when studies give us fewer things to worry about---bird


Cancer Epidemiol Biomarkers Prev. 2013 May;22(5):993-6. doi: 10.1158/1055-9965.EPI-13-0139. Epub 2013 Apr 2.
Null Association between Tamoxifen Use and Dementia in Danish Breast Cancer Patients.

Ording AG, Jensen AB, Cronin-Fenton D, Pedersen L, Sørensen HT, Lash TL.
Source

Corresponding Author: Anne G. Ording, Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, 8200 Aarhus N, Denmark. ao@dce.au.dk.

Abstract

BACKGROUND:

Concerns have been raised about the risk of dementia associated with antiestrogen adjuvant therapy in breast cancer, but study results have been inconsistent. We examined whether tamoxifen or other endocrine therapy was associated with dementia risk in a large population of patients with breast cancer.
METHODS:

We used Danish nationwide medical registries to identify patients with breast cancer diagnosed between 1990 and 2004, use of endocrine therapy, and subsequent diagnoses of dementia. We used Cox regression to estimate the risk of dementia among patients who received five years of tamoxifen or other endocrine therapies.
RESULTS:

The study included 16,419 patients with breast cancer. In this cohort, 37% were unexposed to endocrine therapy, 9% had five years of tamoxifen therapy, and 54% had other endocrine regimens, some of them containing tamoxifen for less than five years with subsequent aromatase inhibitor therapy. Tamoxifen therapy was associated with a near-null risk of dementia [HR, 1.4; 95% confidence interval (CI), 1.0-1.9], and a null association was observed after death was taken into account as a competing risk (sub-HR, 1.0; 95% CI, 0.76-1.4).
CONCLUSIONS:

No clinically relevant association between use of tamoxifen or other endocrine therapy and risk of dementia was observed. Impact: Our result contradicts earlier research findings suggesting tamoxifen and other endocrine therapies increase the risk of dementia in breast cancer patients. Cancer Epidemiol Biomarkers Prev; 22(5); 993-6. ©2013 AACR.


PMID:23548343 [PubMed - in process]
__________________
Male Breast Cancer, DX 5/15/09, IDC, STAGE 1, 1.7 cm, HER2+++, ER+(95%)/PR+(75%), Ki67 40%, grade 3, 0/5 nodes, TX: mastectomy, TCH finished 7/19/10, radiation 6 wks., Tamoxifen on going, bisphosphonate 24 mos.
1rarebird is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -7. The time now is 02:59 AM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2018, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007
free webpage hit counter