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Old 02-08-2012, 02:00 AM   #1
Jackie07
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New Therapies in Her2-positive Breast Cancer

Cancer Treat Rev. 2012 Feb 2. [Epub ahead of print]

New therapies in HER2-positive breast cancer: A major step towards a cure of the disease?
Awada A, Bozovic-Spasojevic I, Chow L.

Source

Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.

Abstract

Overexpression of the human epidermal growth factor receptor 2 (HER2) predicts a poor prognosis in metastatic breast cancer. While the introduction of HER2-targeted therapies, such as the monoclonal antibody trastuzumab and the small-molecule tyrosine kinase inhibitor lapatinib, has significantly improved outcomes in HER2+ breast cancer compared with previously available therapies, use of these targeted therapies is often limited by the development of drug resistance and tolerability issues. These limitations create the need for further development and investigation of new targeted therapies that show potent and selective inhibition of these targets or closely connected molecular pathways.

Recently, several agents have demonstrated promising activity in HER2+ metastatic breast cancer, either as monotherapy or in combination therapy, including the tyrosine-kinase inhibitors neratinib (HKI-272) and afatinib (BIBW-2992) and the anti-HER2 monoclonal antibodies pertuzumab and trastuzumab-DM1 (T-DM1). Agents that target other molecular pathways, such as the vascular endothelial growth factor receptor, mammalian target of rapamycin, PI3-kinases, insulin-like growth factor (IGFR), HSP-90, and other kinases also have potential, in combination with anti-HER2 and/or other systemic therapies, to be active in this subtype of breast cancer.

Innovative clinical studies are required in well-characterized patient populations to define the true clinical value of these emerging new approaches.

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Last edited by Jackie07; 02-08-2012 at 02:11 AM..
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Old 09-26-2012, 08:36 AM   #2
vonny
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Re: New Therapies in Her2-positive Breast Cancer

Jackie
There is so much to this site that I am still finding my way around it. Whenever I am feeling a little despondent and need the extra boost I come on here and scroll through all the positive and amazing threads…..it never fails me!
Thank you for posting this
Love
Yvonne xx
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Old 09-28-2012, 02:48 PM   #3
Jackie07
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Latest treatment options for Her2-positive Breast Cancer

From the latest issue of Cure magazine :

http://curetoday.com/her2_updates2012

["Free to cancer patients, survivors, caregivers and healthcare professionals in the U.S." Click on the 'Subscribe' button on top of the link.]
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Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016

"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe

Last edited by Jackie07; 09-28-2012 at 02:54 PM..
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Old 01-23-2013, 05:29 AM   #4
Kkmom
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Re: New Therapies in Her2-positive Breast Cancer

Thank you Jackie07 for the article. My cancer is not metastatic. It is still early stage. My bc is a stage II. At first, when my doctor talked with me about the clinical trial. I was wondering why is she offering me this option so early in the game.
But as I am understanding perjetta and herceptin has worked well with women with more advanced stage cancer.
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