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03-11-2010, 10:59 AM
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#1
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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Of interest to Her2+ ER+
Risk of Recurrent Disease in HER2-Positive Patients
I had posted this in the "Articles of Interest" section, but thought I would move it over here, too. The article contained some info I had not seen before and thought it might generate some discussion amoungst the Her2+ ER+ people.
Daniel F. Hayes, MD:
What I find interesting about this study is that with ER-positive cancer there is an ongoing risk of recurrence for a long period of time. It looks as though there is a secondary spike between 8 and 12 years. Dr. Goss did not necessarily agree with that, but there have been some reports of this, whereas in ER-negative patients, the tumor recurs within the first 5-7 years or it does not recur.
Here is the entire article: http://www.clinicaloptions.com/Oncol...Page%2012.aspx
Hopeful also pasted the article there.
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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03-11-2010, 12:35 PM
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#2
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: Of interest to Her2+ ER+
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03-11-2010, 12:37 PM
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#3
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Re: Of interest to Her2+ ER+
Barbara,
FYI, I cut and pasted the discussion into your other thread, because you have to register (free) for the link to work, but registration for that site requires providing more personal information than some may be comfortable with. Like you, I thought the information important enough to be shared with the group.
Hopeful
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03-11-2010, 12:51 PM
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#4
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: Of interest to Her2+ ER+
Hi Barbara,
As a triple positive who has stayed NED without trastuzumab or an AI and has just passed the 8 year mark, I too am listening to this discussion.
A question I have is:
Christine's recurrence a while back leads me to wonder what the frequency is for these late recurrences to occur primarily in the CNS, where monitoring is not as commonly done in general and given that it may be that the symptoms are not recognized as quickly as they are when metastasis occurs elsewhere.
A.A.
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03-11-2010, 12:59 PM
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#5
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Re: Of interest to Her2+ ER+
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03-11-2010, 01:50 PM
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#6
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Senior Member
Join Date: Feb 2007
Location: Paris, France
Posts: 858
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Re: Of interest to Her2+ ER+
Thanks Barbara. This article really got me panicked. I still have these headaches and am going for a brain MRI next Tuesday. But I prefer to be informed. Michka
__________________
08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex
12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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03-11-2010, 03:10 PM
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#7
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Senior Member
Join Date: May 2009
Posts: 510
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Re: Of interest to Her2+ ER+
Is anyone aware of a study offering maintenance Herceptin/Tykerb/TDM-1 for those on Tamoxifen? Seems to me that the article makes the point that those of us ER+/HER-2+ could benefit from doing both HER-2 therapy and endocrine therapy at the same time.
I'm still on my full year of Herceptin and taking Tamoxifen as well, but I'll be worried when my Herceptin year ends to just be on Tamoxifen...
__________________
ER+ (30%)/PR-/HER-2+, stage 3
Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin
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