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09-26-2007, 07:14 PM
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#1
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Senior Member
Join Date: Sep 2005
Location: Riverside, CA
Posts: 484
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Update after Gamma Knife
Well, I had the Gamma Knife performed at Cedars-Sinai on Monday. This is the brain lesion that was treated in Jan 06 via X-knife, and surgically removed in March 07.
It had grown an additional 1 mm in 10 days, it was 2 mm on the 14th of September and the pre Gamma MRI on the 24th of Sept, showed it to be 3 mm.
In addition, it had grown a "tail" which means it was getting ready to burrow down into my brain. Scary stuff! It was almost like it was an extra-terrestrial invador, starting to try to burrow down at only 3 mm is pretty amazing.
I guess this little stubborn brain mets lesion is really aggressive and so far has eluded fully being captured. Send your positive thoughts and prayers my way that this latest Gamma Knife treatment will take care of it once and for all...
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09-26-2007, 07:22 PM
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#2
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Senior Member
Join Date: May 2006
Location: San Marcos, CA
Posts: 48
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I'm sorry you're having to deal with this lesion again, Esther. Thoughts and prayers coming your way.
__________________
Mother/daughter bc patients (should have signed up for spa treatments instead of chemo! Who knew?)
Mom:
dx 2002 age 62
Stage IIIB, triple positive
FACx6, tamoxifen
2004 Stage IV, started Herceptin
mets to pleura, lungs, bone
tried Arimedex, Faslodex, Zometa, Navelbine, Taxol, Taxotere, Gemzar, Carboplatin, Abraxane, Xeloda
June 2007 new mets to nodes and pericardiam
Switched from Xeloda/Herceptin to Xeloda/Tykerb
September 2007 Failed X/T. Switched back to Xeloda/Herceptin, added Gemzar
Jan 2008 Taxol/Tykerb
Feb 2008 Tykerb as a single agent
Me:
dx 2007 age 38
Stage IIA pleomorphic ILC ER/PR + HER2 -
FACx6, tamoxifen
Mom to 2, ages 6 and 9
Trying to find a new hobby besides going to the cancer center.
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09-26-2007, 07:42 PM
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#3
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Senior Member
Join Date: Mar 2007
Location: CHARLOTTE NC USA
Home town (ECUADOR) South America
Posts: 542
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Esther I think you are so lucky ...to find it and to radiated when is so small ...I'm happy for you thanks for the updated
__________________
Lily Diag April/06 5 months after give birth my son Max stage IV mets on liver (5 tumors) 38 year old, her2+++ and ER+PR+ from32 nodes 4 positives mastectomy right breast chemo before surgery herceptin/carboplatin/taxotere ,clear and surgery have radiation 20, `& then herceptin and tamoxifen NED until Aug/07 body only then 'n June 04-06-07 .1 lesion of 1.6 cm on cerebellum ...novalis ,open sugery 5m.m brain met again novalis, 4mm.In the liver. Waiting 2 months now 3 tumors enroll on T-MCC trial start first infusion Nov 5/07 at Dec 17 scan show one tumor despair the 2nd and 3th diminish Doc said great results until March/08 ct scan show progression 03-05-08 start tykerb & xeloda
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09-26-2007, 07:45 PM
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#4
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Senior Member
Join Date: Sep 2005
Posts: 556
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I am sending all positive thoughts and wishing a clean MRI next.
Julie
__________________
Diagnosed in Sept 2004 while pregnant with the second child. Stage 3b, tumor 4.5cm, 4 auxillary and supraclav node positive. Her2+++ FISH 9.4 and er-,pr-.
Had dose dense neoadjuvant AC,Taxol then mastectomy,radiation+xeloda+Herceptin.
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09-26-2007, 07:50 PM
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#5
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Senior Member
Join Date: Jun 2006
Location: Bradenton,FL
Posts: 977
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Dear Esther,
I am visualizing this little cancer "alien" and the Gamma knife OBLITERATING it quickly AND quietly from your body...
Loving hugs,marcia
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09-26-2007, 07:57 PM
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#6
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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Dear Esther,
Sending positive thoughts your way from Canada to totally destroy that little monster.
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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09-26-2007, 08:28 PM
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#7
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Senior Member
Join Date: Sep 2005
Location: Vancouver, Canada
Posts: 329
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Another positive energy your way from Canada Vancouver. You have to let me know when you are coming to Whistler for skiing. Best luck to you!
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09-26-2007, 08:34 PM
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#8
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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That dastardly little brain met couldn't possibly know who it is dealing with! Or what power there is coming to destroy it! I'm believing it is done and you're on the mend. You're one brave gal! God bless you and bring the end of that "invader"! Mary Anne
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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09-26-2007, 08:39 PM
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#9
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Senior Member
Join Date: Sep 2006
Location: Houston, Texas
Posts: 624
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I am sending you positive thoughts, energy and prayers your way. I hoping that the gamma knife obliterated the alien creature, forever! Best wishes.
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09-26-2007, 08:46 PM
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#10
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Dear Esther,
I believe in the power of prayer. I know that all your Her2 sisters are behind you 200% and we will send you all positive energy and prayers.
You are my hero!
Hugs,
jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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09-26-2007, 08:51 PM
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#11
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Esther,
Thanks for keeping us updated as I've been thinking about you. I pray that this GammaKnife procedure blasted the alien into oblivion! You have been through so much and have stayed so strong and positive. I know that this GammaKnife has taken care of this pesky beast. You are in my prayers.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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09-26-2007, 09:29 PM
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#12
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Senior Member
Join Date: Feb 2006
Posts: 1,014
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Esther, my prayers are with you. May you stay strong and upbeat. Keep the faith and know I am praying for you..sherryg
__________________
Sherry
Diagnosed: December , 2005 at age 44
13+ positive lymph nodes
Stage IV , Her2+, 2 small mets to lungsChemo Started: Jan, 2006
4 months Taxotere, Xeloda, Hercepin
NED since April 2006!!
36 Rads to follow with weekly Herceptin indefinately
8 years NED now
Scans every year
Life is not about avoiding the thunderstorms, it's about learning to dance in the rain!
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09-27-2007, 04:58 AM
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#13
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Esther
Sending positive thoughts and prayers that this little met is gone forever and you are off to new adventures soon!
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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09-27-2007, 06:50 AM
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#14
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Senior Member
Join Date: Nov 2005
Location: Ireland
Posts: 3,463
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Esther sending lots of positive thoughts and good wishes to you, I hope it's beat for good this time,you've been through enough!
__________________
Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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09-27-2007, 07:39 AM
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#15
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Senior Member
Join Date: Aug 2006
Posts: 492
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I am picturing Sigourney Waever with her shaved head blasting that sucker!
Hope you have a smooth recovery and great results. How are you feeling after the surgery?
__________________
Are we there yet?
Dx 10/05 IDC, multi-focal, triple +, 5 nodes+
MRM, 4 DD A/C, 12 weekly taxol + herceptin
rads concurrent with taxol/herceptin
finished herceptin 01/08
ooph, Arimidex, bilateral DIEP reconstruction
NED
Univ. of WA, Seattle vaccine trial '07
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09-27-2007, 08:40 AM
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#16
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Senior Member
Join Date: Jan 2007
Posts: 144
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Mets be gone!
Sending you postive thoughts and energy to fight this little bugger. Hope all goes well and it is removed for GOOD!
Rest and take care of yourself.
Emelie
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09-27-2007, 10:30 AM
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#17
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Senior Member
Join Date: Nov 2006
Posts: 42
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Sending you and your medical team prayers.....
__________________
Susie Q - North San Diego
Diagnosis at Age 41 on 10/6/06
~3cm Invasive Ductal Carcinoma Left Breast Stage II
~ER+ 45% Moderate ~ PR+ 62% Strong
~HER2/neu +++
~Sentinel Node Biopsy - Negative Four Nodes
~BRAC1/BRAC2 Negative
~Neo-adjuvant Chemo:6 rounds-every Three
Weeks of Taxotere & Carboplatin & Herceptin
Weekly Completed on 2/7/2007
~Lumpectomy (after chemo) 3/12/2007
~Switched to Every 3-week Herceptin 3/21/2007 for nine more months.
~Radiation May through June 2007 (35 rads total)
~Hormone therapy Lupron Injections + Arimidex
~Lymphedema Challenged!
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09-27-2007, 12:10 PM
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#18
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Senior Member
Join Date: Nov 2005
Location: Lincoln, Rhode Island
Posts: 371
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My prayers and thoughts are with you. I pray and hope this critter is gone for ever!
__________________
Love and Hope
Karen
IDC
DX 1998 STAGE I ER+/ PR+
AC CHEMO TILL FEB 1999
Tamxofin till 2001
2001 exstensive liver mets and mets to lungs
Started weekly taxol
Jan 2002 found out I was strongly HER2POS+++ started herceptin continued with taxol and herceptin till June 2002 then from June 2002 till Jan 2005 just herceptin and Arimidex
2005 Navelbine herceptin had RFA Then back on taxol with herceptin
April 2006 progression again went on clinical trial with tykrerb/herceptin progressed on the started Xeloda/ herceptin
Feb 2007 started Doxil
August 2007 Taxotere,Carboplatin and Herceptin exstensive mets to liver and pancreas
October 2007 Had to stop Carboplatin due to sever allergic reaction
Jan 2008
Stopped Taxotere due to progression now on Gemzar and Herceptin
March 2008 Starting Carboplatin, Abraxane, and Herceptin.
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09-27-2007, 01:10 PM
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#19
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Esther,
of course my prayers are with you that this procedure slaps that little bugger down permanently. And again, your exquisite sensitivity to noticing so small a lesion before it got even nastier is amazing
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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09-28-2007, 01:54 PM
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#20
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Senior Member
Join Date: Aug 2001
Location: Oregon
Posts: 1,756
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Esther, hope you're feeling better now; is the nausea gone? That is one of my least favorite symptoms.
Not that I have ANY favorites, ha.
<3 Lolly
__________________
Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.
Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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