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10-31-2009, 01:11 PM
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#1
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Senior Member
Join Date: Sep 2005
Location: Newton, MA
Posts: 951
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An Open Conversation on Metastatic Breast Cancer
I just returned from Dana Farber where I attended the symposium on Metastatic Breast Cancer. The discussions and talks were taped and I will post the link when it becomes available.
I found it interesting that the prognoses for HER2+ breast cancer has changed positively in comparison to other types of breast cancer. I also found it noteworthy that Dr. Winer feels HER2+ cancers have a good chance of being cured in the next 5 to 10 years. Let's hope that it will be closer to 5.
Happy Halloween!
Barbara H.
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10-31-2009, 01:16 PM
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#2
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Senior Member
Join Date: Oct 2007
Location: Scottsdale,AZ
Posts: 43
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Re: An Open Conversation on Metastatic Breast Cancer
Wow! How exciting! I hope it's a cure in 5 years as well! Or sooner!!!!!!
I can't wait to catch the link when it's available.
Thx for the info,
Barb
__________________
Dx 5/1/07 (age 47), Left IDC
ER less than 5% +, PR -, HER+ FISH 5.4
Lumpectomy 5/07, Quadrantectomy 6/07
AC 7/07 -10/07, Liver mets dx 9/07 (liver bx)
Taxotere/Herceptin 10/07 -12/07
Herceptin only 1/08 - 7/08
Mastectomy 3/08, RADS 4/08 - 5/08
Brain MRI 5/08 clear
Gemzar/Herceptin 7/08-9/08
Lymphedema 8/08
RADS/Hyperthermia 10/08-11/08
Abraxane/Herceptin 12/08-3/09
Doxil/Herceptin 3/09 to 5/09
Xeloda/Tykerb 6/09-10/09
Navelbine/Xeloda/Tykerb 10/09-12/09
Tykerb/Herceptin 1/11/10
Tykerb/Herceptin/Ixempra 2/1/10
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10-31-2009, 01:38 PM
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#3
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: An Open Conversation on Metastatic Breast Cancer
And the other types of BC? Any mention of the concept that breast cancer stem cells being Her2+, ER-?
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10-31-2009, 02:37 PM
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#4
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Senior Member
Join Date: Sep 2005
Location: Newton, MA
Posts: 951
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Re: An Open Conversation on Metastatic Breast Cancer
All types of breast cancer were discussed. There was not much mentioned about HER2+ that is also PR+ because the main focus in the future will be targeted therapy. There seems to be less interest in developing new chemotherapy drugs because of the increased effectiveness with targeted therapy. I did not take notes and do not wish to incorrectly post the information that was provided. I will post the link when it becomes available.
Barbara H.
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10-31-2009, 06:49 PM
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#5
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Senior Member
Join Date: Jun 2009
Location: Los Angeles, CA
Posts: 309
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Re: An Open Conversation on Metastatic Breast Cancer
Great news Barbara--
__________________
DX: 11/08 Age: 53
Surgery: 1/09
Bilat Mastectomy, no reconstruction
ILC-4 tumors-1.7 cm,1.5 cm (2).8 cm
DCIS-11 cm
All tumors Grade 3
All tumors ER-0%/PR-0%
All tumors HER2+
IHC-all tumors Overexpression/borderline
FISH 2 tumors Her2-Negative
FISH 2 tumors Her2+ Equivocal
Stage I, 0/1 nodes
LVI-Indeterminate(treated as positive)
SPR Score 8/9
Ki-67 20%
BRCA genetic test 1/2=negative
Chemo: 6 rounds TAC Feb-June 2009 w/Neulasta
Herceptin: 6/12/09-6/4/10 52weeks
HNPCC genetic test: negative
Port Placement-9/23/09 Port Removal 6/25/10
Echo's every 3 months-All normal
2/09 Staging PET/CT showed 0.2 micronodule upper R lobe-lung-Onc does not think this is mets--
6/5/09 AND 10/09 CT scan 0.2 micronodule unchanged
1/10-PET/CT-uptake in nasopharynx-
1/10-MRI All normal
6/10-Bone Scan-clear
12/10-PET/CT-All Clear-NED
12/11-PET-All Clear-NED
12/12-PET-All Clear-NED
12/13-CT w/contrast Head, Torso-All Clear
12/14-CT w/contrast Head-All Clear
2/15-Core needle biopsy-R scar line
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10-31-2009, 06:51 PM
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#6
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Senior Member
Join Date: Jun 2009
Location: Los Angeles, CA
Posts: 309
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Re: An Open Conversation on Metastatic Breast Cancer
sorry-forgot to ask about ER and PR negatives?
Or triple negatives??
2 of my 4 tumors were triple negative
the other 2 were ER/PR negative and Her2+
__________________
DX: 11/08 Age: 53
Surgery: 1/09
Bilat Mastectomy, no reconstruction
ILC-4 tumors-1.7 cm,1.5 cm (2).8 cm
DCIS-11 cm
All tumors Grade 3
All tumors ER-0%/PR-0%
All tumors HER2+
IHC-all tumors Overexpression/borderline
FISH 2 tumors Her2-Negative
FISH 2 tumors Her2+ Equivocal
Stage I, 0/1 nodes
LVI-Indeterminate(treated as positive)
SPR Score 8/9
Ki-67 20%
BRCA genetic test 1/2=negative
Chemo: 6 rounds TAC Feb-June 2009 w/Neulasta
Herceptin: 6/12/09-6/4/10 52weeks
HNPCC genetic test: negative
Port Placement-9/23/09 Port Removal 6/25/10
Echo's every 3 months-All normal
2/09 Staging PET/CT showed 0.2 micronodule upper R lobe-lung-Onc does not think this is mets--
6/5/09 AND 10/09 CT scan 0.2 micronodule unchanged
1/10-PET/CT-uptake in nasopharynx-
1/10-MRI All normal
6/10-Bone Scan-clear
12/10-PET/CT-All Clear-NED
12/11-PET-All Clear-NED
12/12-PET-All Clear-NED
12/13-CT w/contrast Head, Torso-All Clear
12/14-CT w/contrast Head-All Clear
2/15-Core needle biopsy-R scar line
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10-31-2009, 08:33 PM
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#7
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Senior Member
Join Date: Feb 2006
Posts: 1,014
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Re: An Open Conversation on Metastatic Breast Cancer
Wish they would hurry that cure up, 5 years seems like such a long time. At least they have something...sherry
__________________
Sherry
Diagnosed: December , 2005 at age 44
13+ positive lymph nodes
Stage IV , Her2+, 2 small mets to lungsChemo Started: Jan, 2006
4 months Taxotere, Xeloda, Hercepin
NED since April 2006!!
36 Rads to follow with weekly Herceptin indefinately
8 years NED now
Scans every year
Life is not about avoiding the thunderstorms, it's about learning to dance in the rain!
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11-01-2009, 11:59 AM
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#8
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Senior Member
Join Date: Aug 2009
Posts: 94
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Re: An Open Conversation on Metastatic Breast Cancer
I feel hopeful.
margie
Dcis - 8/8/08
lumpectomy 9/2/08
liver met 10/14/08
tch 11/01/08 - 2/11/08
herceptin 3x wk
vaccine 6/09-last one 11/09
NED since 1/23/09
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11-02-2009, 12:05 AM
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#9
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Senior Member
Join Date: Aug 2008
Location: San Francisco
Posts: 260
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Re: An Open Conversation on Metastatic Breast Cancer
Yes, Dr. Winer mentioned the 10 year prediction at the Young Survivors Conference in Dallas this past February. He inspired such hope and optimism in us HER2 gals. Praying its closer to 5 and that I can be here for the cure!
__________________
4/17/08: Dx Stage IV at age 30 - extensive mets to liver, lungs, and bones. Er/Pr-, Her2+++
April 08-Aug 08:Taxotere, Cytoxan, Herceptin, Zometa - complete response!
Sept 08-Dec 08: Herceptin +Zometa for maintenance.
Jan 09-April 09: Brain mets. Add Tykerb. Watch and wait.
April 09: Gamma Knife 10 brain mets, add Xeloda.
Sept 09: Gamma Knife to 1 brain met.
Nov 09- April 10: Lung progression, add Gemzar to Herceptin, Zometa.
May 10- Sept 10: HER2 Vaccine Trial
Sept 10: Add Tykerb for more brain mets.
Oct 10: Gamma Knife to 7 brain mets.
Dec 10: Switch from Zometa to Denosumab.
Jan 11: Gamma Knife to 3 brain mets.
March 11: Gemzar/Herceptin for lung/bone progression.
April 11: More brain mets - Intrathecal Herceptin
June 11: Ixempra/Herceptin for lung, soft tissue progression.
Aug 11: Gamma Knife
Sep 11: Abraxane/Herceptin
Future: NED
Send me a PM if you'd like to follow my journey on Caringbridge.
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