HonCode

Go Back   HER2 Support Group Forums > Articles of Interest
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 05-09-2005, 07:05 PM   #1
Lani
Guest
 
Posts: n/a
http://www.medscape.com/viewarticle/504470

can read it in a special supplement at the JCO website--April 10issue
  Reply With Quote
Old 05-10-2005, 06:57 AM   #2
Rich
Guest
 
Posts: n/a
I think I need a translation on this one.
  Reply With Quote
Old 05-11-2005, 07:11 AM   #3
*_Christine MH_*
Guest
 
Posts: n/a
"There was early tumor regression with a median decrease of –20.0% (range. 0% to 60.4%) after only 3 weeks of trastuzumab, and eight patients (23%) had a partial response. Consistent with the clinical regressions, apoptosis was significantly induced (median increase from 3.5% to 4.7%; P = .006) within week 1, a 35% increase above baseline. No significant change in epidermal growth factor receptor score was observed in week 1, without changes in total or p-HER-2 expression. Tumors with high baseline Ki67 were less likely to respond (P = .02). "

Partial Translation (correct me if anything here is wrong):

After three weeks of receiving herceptin before surgery, half of early BC patients had their tumors shrink by 20% or more, with the range for all patients being 0 to 60%, and 8 had a partial response (meaning that their tumors shrunk by more than 50%). As expected from the results in the laboratory, cell death significantly increased within one week to 35% above the baseline (the average increase was 3.5% to 4.7, and there was only a 0.6% chance that this happened by coincidence).

[Unclear: No significant change in epidermal growth factor receptor score was observed in week 1, without changes in total or p-HER-2 expression. (Not clear exactly, but the Medline bit said that herceptin in humans does not downregulate HER2)]

Tumors that were highly proliferative to begin with were less likely to shrink (and there is only a 2% chance that this connection is just a coincidence).

End translation.

Thanks for that Lani. It is really interesting that herceptin works best for less proliferative cancers, which is exactly the opposite of chemo.

A little more than a year ago, I had the choice between putting my name down for the HERA trial and perhaps ending up in the control group or subjecting myself to four rounds of taxotere on top of the six rounds of chemo I had had before surgery. I followed the advice of my oncologist, who was leaning towards taxotere, partly because he doubted that I would make HERA in time. With all of the excitement about the forthcoming HERA trial results, I have been wondering whether I did the right thing for my highly proliferative cancer. Perhaps I did.
  Reply With Quote
Old 05-11-2005, 06:09 PM   #4
Rich
Guest
 
Posts: n/a
How do you know your tumor is "highly" proliferative?
  Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On

Forum Jump


All times are GMT -7. The time now is 05:31 AM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021
free webpage hit counter