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06-21-2011, 01:35 PM
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#1
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Excercise/activity
Recent Results Cancer Res. 2011;186:189-215.
Physical activity and breast cancer survivorship.
Schmitz K.
Source
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 903 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA. Schmitz@mail.med.upenn.edu
Abstract
A diagnosis of breast cancer is associated with treatments that have physiologic effects beyond the intended curative therapy. The first section of this chapter provides and integrative physiology review of the effects of breast cancer treatment on the body systems used by and affected by physical activity, including effects of chemotherapy, radiation, and surgery. In later sections, we review the literature on physical activity and breast cancer from the point of diagnosis and for the balance of life. The efficacy of physical activity for supportive cancer care outcomes is reviewed separately from the purported usefulness of physical activity for disease-free and overall survival from breast cancer. The current evidence supports the safety of physical activity during and after breast cancer therapy. The supportive cancer care outcomes for which there is sufficient evidence of efficacy during and after breast cancer treatment include fitness, fatigue, body size, and quality of life. Further, there is growing evidence that upper body exercise does not pose additional risk for negative lymphedema outcomes among survivors with and at risk for lymphedema. For overall survival, the evidence is largely observational, with sufficient evidence that physical activity does confer benefit. Finally, we outline future directions for research on physical activity among breast cancer survivors, including expanding to focus on subsets of the population not included in most prior studies (minority women and older women), tailoring of interventions to stages of cancer most likely to benefit, expanding to study women with metastatic cancer, and new modes of exercise, such as team sports, martial arts, and Pilates.
- PMID:
- 21113765
- [PubMed - indexed for MEDLINE]
Cancer Res. 2011 Jun 1;71(11):3889-95. Epub 2011 May 24.
Physical activity after diagnosis and risk of prostate cancer progression: data from the cancer of the prostate strategic urologic research endeavor.
Richman EL, Kenfield SA, Stampfer MJ, Paciorek A, Carroll PR, Chan JM.
LINK
Source
Authors' Affiliations: Departments of Epidemiology and Nutrition, Harvard School of Public Health; The Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Departments of Urology and Epidemiology and Biostatistics, School of Medicine; and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Abstract
Vigorous activity after diagnosis was recently reported to be inversely associated with prostate cancer-specific mortality. However, men with metastatic disease may decrease their activity due to their disease; thus, a causal interpretation is uncertain. We therefore prospectively examined vigorous activity and brisk walking after diagnosis in relation to risk of prostate cancer progression, an outcome less susceptible to reverse causation, among 1,455 men diagnosed with clinically localized prostate cancer. Cox proportional hazards regression was used to examine vigorous activity, nonvigorous activity, walking duration, and walking pace after diagnosis and risk of prostate cancer progression. We observed 117 events (45 biochemical recurrences, 66 secondary treatments, 3 bone metastases, 3 prostate cancer deaths) during 2,750 person-years. Walking accounted for nearly half of all activity. Men who walked briskly for 3 h/wk or more had a 57% lower rate of progression than men who walked at an easy pace for less than 3 h/wk (HR = 0.43; 95% CI: 0.21-0.91; P = 0.03). Walking pace was associated with decreased risk of progression independent of duration (HR brisk vs. easy pace = 0.52; 95% CI: 0.29-0.91; P(trend) = 0.01). Few men engaged in vigorous activity, but there was a suggestive inverse association (HR ≥3 h/wk vs. none = 0.63; 95% CI: 0.32-1.23; P(trend) = 0.17). Walking duration and total nonvigorous activity were not associated with risk of progression independent of pace or vigorous activity, respectively. Brisk walking after diagnosis may inhibit or delay prostate cancer progression among men diagnosed with clinically localized prostate cancer. Cancer Res; 71(11); 3889-95. ©2011 AACR.
- PMID:
- 21610110
- [PubMed - in process]
- PMCID: PMC3107352
- [Available on 2012/6/1]
Obesity (Silver Spring). 2009 Aug;17(8):1534-41. Epub 2009 Feb 19.
Exercise improves body fat, lean mass, and bone mass in breast cancer survivors.
Irwin ML, Alvarez-Reeves M, Cadmus L, Mierzejewski E, Mayne ST, Yu H, Chung GG, Jones B, Knobf MT, DiPietro L.
Source
Yale School of Medicine, New Haven, Connecticut, USA. melinda.irwin@yale.edu
Abstract
Given the negative effects of a breast cancer diagnosis and its treatments on body weight and bone mass, we investigated the effects of a 6-month randomized controlled aerobic exercise intervention vs. usual care on body composition in breast cancer survivors. Secondary aims were to examine the effects stratified by important prognostic and physiologic variables. Seventy-five physically inactive postmenopausal breast cancer survivors were recruited through the Yale-New Haven Hospital Tumor Registry and randomly assigned to an exercise (n = 37) or usual care (n = 38) group. The exercise group participated in 150 min/week of supervised gym- and home-based moderate-intensity aerobic exercise. The usual care group was instructed to maintain their current physical activity level. Body composition was assessed at baseline and 6-months through dual-energy X-ray absorptiometry (DXA) by one radiologist blinded to the intervention group of the participants. On an average, exercisers increased moderate-intensity aerobic exercise by 129 min/week over and above baseline levels compared with 45 min/week among usual care participants (P < 0.001). Exercisers experienced decreases in percent body fat (P = 0.0022) and increases in lean mass (P = 0.047) compared with increases in body fat and decreases in lean mass in usual care participants. Bone mineral density (BMD) was also maintained among exercisers compared with a loss among usual care participants (P = 0.043). In summary, moderate-intensity aerobic exercise, such as brisk walking, produces favorable changes in body composition that may improve breast cancer prognosis.
- PMID:
- 19629060
- [PubMed - indexed for MEDLINE]
- PMCID: PMC2841468
Free PMC Article
J Cancer Surviv. 2008 Dec;2(4):253-61. Epub 2008 Oct 16.
Dimensions of physical activity and their relationship to physical and emotional symptoms in breast cancer survivors.
Basen-Engquist K, Hughes D, Perkins H, Shinn E, Taylor CC.
Source
Department of Behavioral Science, The University of Texas M. D. Anderson Cancer Center, P.O. Box 301439, Unit 1330, Houston, TX 77230-1439, USA. kbasenen@mdanderson.org
Abstract
BACKGROUND:
Many breast cancer survivors experience long term sequelae, including fatigue, decreased physical functioning, pain, and psychological distress. Physical activity can ameliorate these problems, but there is little research on how activity should be performed to be most beneficial. This study explores how dimensions of physical activity (total energy expenditure, frequency, and duration) are associated with symptoms among breast cancer survivors.
METHODS:
We conducted a secondary analysis of data on physical activity behavior and symptoms in a cross-sectional study (n = 148) of breast cancer survivors who were off treatment and had been diagnosed within the past 5 years.
RESULTS:
Multivariate analyses showed that total energy expenditure was associated with better general health (p = 0.006) and fewer depressive symptoms (p = 0.014), while frequency of activity was linearly related to physical functioning (p = 0.047), pain (0.057), general health (p < 0.001), and depressive symptoms (p < 0.001). Duration was related to physical functioning, pain, and general health, but the worst outcomes were reported by the participants with the shortest and longest duration of activity (quadratic trend p values = 0.002, 0.003, 0.008, respectively).
DISCUSSION/CONCLUSIONS:
Greater total energy expenditure, higher physical activity frequency, and moderate duration were associated with better outcomes for most symptoms, although there was no relationship between any of the dimensions of physical activity and fatigue. IMPLICATIONS FOR CANCER SURVIVORS: The association of better outcomes with higher energy expenditure, higher frequency of activity, and moderate duration indicates that increasing activity through multiple short bouts may be the most beneficial for breast cancer survivors. However, randomized studies are needed to confirm this finding.
- PMID:
- 18923906
- [PubMed - indexed for MEDLINE]
- PMCID: PMC3076788
Free PMC Article
Ger Med Sci. 2010 Nov 18;8 ![Big Grin](http://her2support.org/vbulletin/images/smilies/biggrin.gif) oc31.
Active exercises utilizing a facilitating device in the treatment of lymphedema resulting from breast cancer therapy.
Guerreiro Godoy Mde F, Oliani AH, Pereira de Godoy JM.
FREE TEXT
Source
Lato Sensu Post Graduation Course on Lymphovenous Rehabilitation of the Medicine School in São José do Rio Preto (FAMERP) and Research CAPES, Brazil.
Abstract
The aim of this study was to evaluate the reduction in volume of arm lymphedema secondary to breast cancer therapy utilizing an exercise facilitating device. Twenty-one women with arm lymphedema resulting from the surgical and radiotherapeutic treatment of breast cancer were randomly selected. Evaluation was made by water-displacement volumetry before and after each session. The patients were submitted to a series of active exercises using a facilitating device for four 12-minute sessions with intervals of 3 minutes between sessions in the sitting position with alignment of the spinal column. The lymphedematous arm was maintained under compression using a cotton-polyester sleeve. The active exercising device used was a mobile flexion bar fixed on a metal base at a height of 30 cm from the tabletop and at a distance of 10 cm from the patient's body. The paired t-test was utilized for statistical analysis with an alpha error of 5% (p-value ≤ 0.05) being considered significant. The initial mean volume of the arms was 2,089.9 and the final volume was 2,023.0 mL with a mean loss of 66.9 mL (p-value <0.001). In conclusion, active exercises utilizing facilitating devices can contribute to a reduction in size of lymphedematous limbs.
- PMID:
- 21139989
- [PubMed - indexed for MEDLINE]
- PMCID: PMC2996058
Can Fam Physician. 2010 Dec;56(12):1277-84.
Management of secondary lymphedema related to breast cancer.
Cheifetz O, Haley L; Breast Cancer Action.
Source
Hamilton Health Sciences, 711 Concession St, Hamilton, ON L8V 1C3. cheifetz@hhsc.ca
FREE TEXT
Abstract
AbstractOBJECTIVE To review recent literature on the management of secondary lymphedema following breast cancer.QUALITY OF EVIDENCE MEDLINE, EMBASE, AMED, PubMed,and the Internet were searched for articles published between 2005 and 2009. Articles were evaluated using Sackett's levels of evidence. The literature search focused on primary research and systematic reviews.MAIN MESSAGE Secondary lymphedema related to breast cancer is an ongoing challenge. Evidence suggests that there are several safe and beneficial treatments, including complex decongestive therapy, physiotherapy, and exercise. Furthermore, resistive exercises,previously contraindicated on the affected side, have been found to be both beneficial and safe with careful progression and monitoring. Exercise guidelines and patient education topics are presented with a comprehensive reference list for further reading.CONCLUSION Advances in cancer treatment, cancer and exercise research, and lymphedema management require that physicians have a basic understanding of the current evidence to provide appropriate patient education and referral.
- PMID:
- 21375063
- [PubMed - indexed for MEDLINE]
- PMCID: PMC3001918
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06-21-2011, 01:38 PM
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#2
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: Excercise/activity
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06-21-2011, 01:38 PM
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#3
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: Excercise/activity
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06-21-2011, 08:41 PM
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#4
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Re: Excercise/activity
Thanks rich. I've been thinking about this in terms of supportive care as I transition to something new chemo-wise. Very timely info for me
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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10-07-2011, 11:04 AM
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#5
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: Excercise/activity; evaluation at the cellular level
I wish they would find a way to do a study that compares the difference in bodywise cellular effect. I know my idea is pretty simple.... but the "A ha!" science of simple ideas is real sometimes.
I think that exercise serves another function that we can't see. I think it forces us to take more fresh fluid in, and that slowly forces its way through the body and out, flushing out the cells of any toxin buildup and wastes much faster than it does when we don't exercise.
Smile and laugh -- that is good for us too -- but when I am sweating my way through my hour of daily exercise, the notion is one more idea that gets me through it and gets me to do it again and again.
AlaskaAngel
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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11-15-2011, 06:12 AM
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#6
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Member
Join Date: Apr 2008
Location: Finland
Posts: 19
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Re: Excercise/activity
Latest research from Finland:
Exercise promotes stronger bone in breast cancer patients
Breast cancer patients are now being urged to engage in strenuous exercise following the conclusion of chemotherapy treatments. A new Finnish study shows that exercise increases the density of bone in cancer patients.
Chemotherapy treatments for breast cancer put women at risk for a bone density loss of up to 7 percent a year. The normal loss in healthy women is only one percent.
For this new Finnish study, 573 women who had received treatment for breast cancer were divided into groups of those who engaged in lots of exercise and those who exercised less. The more active group was put through strenuous aerobic and gym exercises on a weekly basis. It was noted that those who exercised more had an increase in bone density. In women below the age of menopause, loss of bone density in the pelvis was completely stopped.
"This is a good result because previously, it has been uncertain if a recovering breast cancer patient, or in general any cancer patient, can exercise immediately following treatment. This study shows that even strenuous exercise is completely safe and, in addition, it is even beneficial," says Dr Tiina Saarto, who heads the cancer clinic for the Helsinki and Uusimaa Hospital District.
Saarto adds that the same thing could be tried with patients recovering from other types of cancer, as well.
"I'd say that this information would be useful for prostate cancer patients. Treatment of prostate cancer also affects the hormones. More study just has to be done into exercise therapies for cancer patients."
The study was carried out between September 2005 and September 2007 at hospitals in Helsinki, Tampere and Turku, as well as at the Institute for Health Promotion Research in Tampere with patients between the ages of 35 and 68.
It is the most extensive study of its kind ever carried out.
Source: yle.fi/uutiset/news/2011/11/
__________________
Kind Regards,
Ursula
Diagnosed 05/07 at age 42
Ductal Invasive Carsinoma Gr III, Stage IIIB:
Primary tumor 35 mm, secondary 21 mm
Node positive 13/23
Er/Pr negative (15 % /15 %)
Her 2+++
Ki-67 80 %
Mastectomy and node evacuation (rt) 05/07
3 x Taxotere + Herceptin (9 weeks)
3 x CEF
6 x Neulasta during chemos
23 x rads
Celebra for joint and PMS pain
NED
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11-15-2011, 03:02 PM
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#7
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Member
Join Date: Apr 2008
Location: Finland
Posts: 19
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Re: Excercise/activity
Concerning the BREX-trial of Finlad, please visit:
http://www.ncbi.nlm.nih.gov/pubmed/21892676
to see the original abstract in Ostheoporos International.
__________________
Kind Regards,
Ursula
Diagnosed 05/07 at age 42
Ductal Invasive Carsinoma Gr III, Stage IIIB:
Primary tumor 35 mm, secondary 21 mm
Node positive 13/23
Er/Pr negative (15 % /15 %)
Her 2+++
Ki-67 80 %
Mastectomy and node evacuation (rt) 05/07
3 x Taxotere + Herceptin (9 weeks)
3 x CEF
6 x Neulasta during chemos
23 x rads
Celebra for joint and PMS pain
NED
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08-28-2012, 09:15 PM
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#8
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Senior Member
Join Date: Apr 2012
Location: Ontario, Canada
Posts: 62
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Re: Excercise/activity
I swim about 25 minutes a day, in addition to gardening. I find it helps dissipate any stress I may have, energizes me, and tones muscles as well as keeping my weigh at a good level.Iam hoping it helps delay or prevent recurrence, although with my stats, I am not that hopeful.
__________________
Dx Nov 2010 at age 65 - 3.5 cm invasive ductal, 8 of 15 nodes. ER-,PR-, HER+++. Lumpectomy, chemo, 6 weeks rads, 52 weeks herceptin finished April 2012.
CAT,PET, bone scan, ultrasound and mammogram in Spring 2012 - NED.
Cherishing every day, but realistically "watching my back" (or should I say "front"?
Eating foods thought to fight cancer, exercising every other day,using my garden as my mecca of peace, and loving my supportive husband more than ever.
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