HonCode

Go Back   HER2 Support Group Forums > Articles of Interest
Reload this Page ovarian abalatioin upregulates her2
Register Gallery FAQ Members List Calendar Today's Posts

Reply
 
Thread Tools Display Modes
Old 09-05-2008, 11:29 AM   #1
RobinP
Senior Member
 
RobinP's Avatar
 
Join Date: Nov 2005
Posts: 943
ovarian abalatioin upregulates her2
http://www.ncbi.nlm.nih.gov/pubmed/14503797

Older article, but interesting that estrogen/progesterone down regulates her2.
__________________
Robin
2002- dx her2 positive DCIS/bc TX Mast, herceptin chemo
RobinP is offline   Reply With Quote
Old 09-28-2008, 11:08 AM   #2
dilly
Junior Member
 
Join Date: Aug 2008
Posts: 2
What does this mean
Is upregulation good or bad?
dilly is offline   Reply With Quote
Old 09-28-2008, 02:07 PM   #3
Janelle
Senior Member
 
Join Date: Nov 2007
Location: Brentwood, CA
Posts: 76
ovarian ablation and HER2
Can you dumb this down for me? Does this study suggest we should consider NOT taking drugs that remove estrogen from our bodies (tamox) if we are triple positives???

Thanks!
Janelle
__________________
Janelle
Diagnosed October 2006 at age 37 wtih grade 3 IDC and high grade DCIS
Stage 1c triple positive, no node involvement but
vascular invasion
multifocal disease
Lumpectomy November, 2006
A/C every 3 weeks (started Jan., 2007 and finished March 2007); followed weekly Taxol (finished June 2007) concurrent with Herceptin (finished March 2008);
Bilateral Mast with immediate recon in Sept 2007; finished recon Dec. 2007
Started 5 years of tamoxifen Nov. 2007; started peptide vaccine clinical trial at MD Anderson October 2008 and finished active part of trial in April 2009 (monthly injections of AE37 peptitde (HLA type specific) with GM-CSF or GM-CSF alone depending on if I was in experimental or control group); started Zometa infusions June 25, 2009- 4mg every 6 months for 3 years (taking it "off-label" to try to prevent mets)
Janelle is offline   Reply With Quote
Old 10-02-2008, 05:31 PM   #4
Nguyen
Senior Member
 
Join Date: Nov 2005
Posts: 516
Upregulation: increasing - downregulation: decreasing.
In this case, increasing the level of her2/neu.

Usually Increasing Her2/neu level indicates recurring disease or resisting disease. HOWEVER, the abstract specifically said that since the CA27.29 was "unchanged", this increasing in Her2/neu can not be used as a disease status indicator.

I don't think just this one study can be used to "...NOT taking drugs...estrogen..." as per Janelle question. Tripple postive (ER+, PR+, Her2+) tumor will "increase" the remaining receptors to compensate when the other is blocked. I think there are data that indicate Her2+ tumor become resistance to tamoxifen faster than Her2 negative.

Nguyen
Nguyen is offline   Reply With Quote
Old 10-02-2008, 08:10 PM   #5
Janelle
Senior Member
 
Join Date: Nov 2007
Location: Brentwood, CA
Posts: 76
Thanks for your input, Nguyen!
__________________
Janelle
Diagnosed October 2006 at age 37 wtih grade 3 IDC and high grade DCIS
Stage 1c triple positive, no node involvement but
vascular invasion
multifocal disease
Lumpectomy November, 2006
A/C every 3 weeks (started Jan., 2007 and finished March 2007); followed weekly Taxol (finished June 2007) concurrent with Herceptin (finished March 2008);
Bilateral Mast with immediate recon in Sept 2007; finished recon Dec. 2007
Started 5 years of tamoxifen Nov. 2007; started peptide vaccine clinical trial at MD Anderson October 2008 and finished active part of trial in April 2009 (monthly injections of AE37 peptitde (HLA type specific) with GM-CSF or GM-CSF alone depending on if I was in experimental or control group); started Zometa infusions June 25, 2009- 4mg every 6 months for 3 years (taking it "off-label" to try to prevent mets)
Janelle is offline   Reply With Quote
Reply

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts
BB code is On
Smilies are On
[IMG] code is On
HTML code is On
Forum Jump


All times are GMT -7. The time now is 07:10 PM.
Contact Us - HER2 Support Group - Archive - Privacy Statement - Top

Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021
free webpage hit counter