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06-10-2011, 12:41 PM
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#1
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Member
Join Date: Jun 2011
Posts: 6
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Herceptin Trastuzumab intrathecal
Dear all,
I try to find out which clinic is applying the Herceptin/ Trastuzumab intrathecal-method. Please, if somebody of you knows something, please let me know. I am asking for my best friend who is suffering from breast cancer HER 2 with brain metastases.
Thank you very much
Nicola
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06-10-2011, 01:14 PM
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#2
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Senior Member
Join Date: Jul 2008
Posts: 186
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Re: Herceptin Trastuzumab intrathecal
Nicola, I know very little about this subject, but maybe more knowledgeable help will check in.
A clinical trial dealing with trastuzumab intrathecal which isn't recruiting as yet is listed on clinicaltrials.gov. No mention is made of brain metastasis but surely people at NorthWestern U might be able to provide further assistance. Most likely you'll need to locate an oncologist who's willing to use Herceptin off-label. Goodluck in finding help for your dear friend.
http://www.clinicaltrials.gov/ct2/sh...tuzumab&rank=1 |
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06-10-2011, 02:55 PM
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#3
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Senior Member
Join Date: Sep 2009
Location: Kensington, CT
Posts: 394
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Re: Herceptin Trastuzumab intrathecal
Nicola,
There are so many knowledgeable people on this web site that can be of help. I think you would get more meaningful information if you could share a summary of your friend's Breast Cancer similar to the signatures you see on the posts.
I too have a single brian met and have thought about intratecal treatment too.
Kris....
__________________
06/08/09 - 55, IDC, IIIA, ER+/PR-/HER+++
Nottingham 6/9 - Grade 2 5.2cm, several nodes
06/23/09 - Neoadjuvant - TCH Herceptin til June
10/07/09 - Finished Chemo
10/27/09 - Mastectomy RB
Path Report: RB No residual tumor pCR,
2 of 15 pos - .5mm largest micromets
12/18/09 - Radiation started (28)
02/05/10 - Finished Radiation
01/11/10 - Started Femara
06/22/10 - Finished Herceptin.. My son's 22nd BD. Hope it's a sign! Hoping for the best.
11/15/10 - Started Walter Reed BC Vaccine trial at
1/04/11 - Sibley Mem. Had to withdraw due to met
01/23/11 - Stage IV - Brain Met 1.6cm 1.7cm
02/03/11 - Gamma Knife (2 fracts to minmize necrosis)
03/01/11 - Gamma Knife
6/11 - Necrosis
7/11 - Necrosis stopped & Tumor progression
8/11 = Now think it's really necrosis
9/11 - Avastin every two weeks -- It's working!! Necrosis is shrinking.
12/11 - Necrosis gone AVASTIN worked.
12/11 - Bone &CT found
Oct '10 - Ran Hartford 1/2 Marathon to Thank Dr. Slamon for Herceptin!
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06-11-2011, 01:00 AM
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#4
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Member
Join Date: Jun 2011
Posts: 6
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Re: Herceptin Trastuzumab intrathecal
Thank you very very much. I will write a signature as you mentionned. Where do you want to ask for this kind of therapy? I wish you all the best for you.
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08-07-2011, 07:13 AM
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#5
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Guest
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Re: Herceptin Trastuzumab intrathecal
My wife started intrathecal herceptin in Chicago on Aug 1, 2011. We have done 2 treatments so far. We are the first in this trial. Those women with LM disease need to enroll in this trial. It can be found on the government web site or you can contact Dr. Raizer at Northwestern University in Chicago. My wife can be reached at cotyav54@yahoo.com |
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08-07-2011, 11:54 PM
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#6
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Guest
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Re: Herceptin Trastuzumab intrathecal
Thank you very much for your kind reply, I will tell my friend. All the best for your wife and for you. Thank you.
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08-08-2011, 01:01 AM
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#7
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: Herceptin Trastuzumab intrathecal
We do have at least one member who has undergone the Intrathecal procedure:
http://her2support.org/vbulletin/sho...cal#post249680
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
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08-08-2011, 02:07 PM
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#8
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Senior Member
Join Date: Aug 2008
Location: San Francisco
Posts: 260
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Re: Herceptin Trastuzumab intrathecal
Hmmm, don't know how I missed this thread. Sorry for not chiming in sooner. Yes, I have been receiving Intrathecal Herceptin since April of this year. I go for a follow-up brain MRI tomorrow to see how things are going. I'll report back as soon as I know the results - hopefully things are still under control. I had a follow-up MRI after only two treatments in May of this year and it showed shrinkage to all four of my active brain mets. All the others that had been treated with Gamma Knife were either still shrinking or gone completely. Let's hope our magic Vitamin H can do the same!
__________________
4/17/08: Dx Stage IV at age 30 - extensive mets to liver, lungs, and bones. Er/Pr-, Her2+++
April 08-Aug 08:Taxotere, Cytoxan, Herceptin, Zometa - complete response!
Sept 08-Dec 08: Herceptin +Zometa for maintenance.
Jan 09-April 09: Brain mets. Add Tykerb. Watch and wait.
April 09: Gamma Knife 10 brain mets, add Xeloda.
Sept 09: Gamma Knife to 1 brain met.
Nov 09- April 10: Lung progression, add Gemzar to Herceptin, Zometa.
May 10- Sept 10: HER2 Vaccine Trial
Sept 10: Add Tykerb for more brain mets.
Oct 10: Gamma Knife to 7 brain mets.
Dec 10: Switch from Zometa to Denosumab.
Jan 11: Gamma Knife to 3 brain mets.
March 11: Gemzar/Herceptin for lung/bone progression.
April 11: More brain mets - Intrathecal Herceptin
June 11: Ixempra/Herceptin for lung, soft tissue progression.
Aug 11: Gamma Knife
Sep 11: Abraxane/Herceptin
Future: NED
Send me a PM if you'd like to follow my journey on Caringbridge.
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08-09-2011, 12:29 PM
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#9
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Senior Member
Join Date: Feb 2008
Location: Georgia
Posts: 1,486
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Re: Herceptin Trastuzumab intrathecal
Courtney,
Hope to hear from you soon.
Amelia
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