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Old 10-09-2010, 09:27 AM   #1
PinkGirl
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Question Liver Enzyme ?

I found out yesterday that my liver enzymes are elevated.
I'll be having an abdominal ultra sound sometime soon and then
re-do the blood work. Can this be nothing serious????
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Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

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Old 10-09-2010, 11:15 AM   #2
AlaskaAngel
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Re: Liver Enzyme ?

Hi Pink Girl,

They bounce around during treatment, and can continue for a while after treatment is done before gradually simmering down. (I know you have been out of treatment for some time but want to say that for those who don't know your history and are comparing their own with yours in thinking about your question.)

Middle-aged women in general often have elevated liver enzymes so it is common in general completely separate from breast cancer, and with breast cancer happening mostly for middle-aged and older women, it can coincide. It is more common with significant alcohol use. Some drugs can cause elevated liver enzymes too.

How elevated they are, and whether they stay that way over time, is important to track. If they are not just mildly elevated and they pretty much stay that way then there is more concern about them. It is important to understand that there are other causes for them, especially at middle age.

Although my copy is not recent, The Liver Disorders Sourcebook by Howard J. Worman, M.D. was helpful to me.

Hope that helps.

AlaskaAngel
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Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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Old 10-09-2010, 12:45 PM   #3
CarolynME
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Re: Liver Enzyme ?

Hi Pnk Girl,

I am really sorry you have to deal with this, and I will be praying for your ultrasound to be clear. It sounds like AlaskaAngel was able to provide you with very helpful information. I will be thinking of you -

Love,

Carolyn
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1/10 Diagnosed with IDC; 3.7 cm tumor
3/10 Left Radical Masectomy; 2 /16 nodes positive - Grade 3 ER+/PR-/HER2+++
4/10 BRCA1 and BRCA2 both negative
4/10 Pet Scan showed another node .07mm positive on the internal mammary area
4/10 ALLTO Trial - randomized for Arm 4 - Taxotere/Carboplatin and Herceptin only (no Tykerb) Began 6 cycles Taxotere/Carboplatin (every three weeks) and Herceptin weekly for eighteen weeks and then every three weeks until the end of April 2011
Radiation to begin 9/2010
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Old 10-09-2010, 12:49 PM   #4
caya
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Re: Liver Enzyme ?

Pink

Could the Arimidex be causing your liver enzymes to be elevated? Just a thought, from Dr. Caya...

Hope it all is a big fat NOTHING!!

all the best
caya
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ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08

Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
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Old 10-09-2010, 01:01 PM   #5
tricia keegan
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Re: Liver Enzyme ?

Pink,

A good friend of mine had the same thing (23 year survivor) and had a liver biopsy, but thankfully it just showed a benign hematoma so it can be nothing serious.
We worry anyway of course, thinking good thoughts for you and hoping it's nothing serious. xx
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Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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Old 10-09-2010, 02:47 PM   #6
Chelee
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Re: Liver Enzyme ?

Pink,
I have had elevated liver enzymes several times. Only one time I thought it was due to TCH since I had just finished my last cycle. But I've had mine elevated 2 and 3 yrs out from chemo and each time it turned out to be nothing. (So yes...it can be nothing serious.)

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 10-09-2010, 04:40 PM   #7
Patb
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Re: Liver Enzyme ?

Do you take any medication for high cholesterol?
Sometime that causes the numbers to rise.
patb
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Diagnosed June, 06, Stage I, Grade3, ER+PR- Her2positive, No Nodes. A/C X 4. Radiation 33 with boost, Herceptin every two weeks until Nov.
07, Arimedex for 5 years. Mugas and Echo and chest xRay. Bone scan of whole Body, and Back of Brain and spine MRI.
CT scan of Lungs every six months
due to two small places. December
2009, bone scan due to bone pain.
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Old 10-09-2010, 04:54 PM   #8
PinkGirl
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Re: Liver Enzyme ?


Thanks everyone. My liver enzymes have not been elevated since I finished chemo. I don't drink alcohol and I don't take any cholesterol meds. I did have a very bad cold/flu sort of thing going on when I had the blood drawn.
I'll keep you posted.
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PinkGirl

Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

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Old 10-09-2010, 07:35 PM   #9
Barbara2
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Re: Liver Enzyme ?

I'm wondering if your cold is what made a rise in your liver enzymes. I remember many years ago, and before breast cancer, I was to have a procedure of some kind done under anesthesia. When speaking with the anesthesiologist, he asked about my liver enzymes because they were high. I remarked that I had had a bad cold, and he shrugged off the high numbers and said that the cold would be the reason for the elevated numbers.

Hoping that is your situation, too. Did your onc order these tests after seeing your bloodwork? How high were the enzymes? Did you let him know you had a bad cold when the blood was drawn?
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Barbara

DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.

Accepting the gift of life, I give thanks for it and live it in fullness.

Last edited by Barbara2; 10-12-2010 at 07:49 PM..
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Old 10-09-2010, 07:57 PM   #10
Gerri
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Re: Liver Enzyme ?

Hey Pink,

Please know that I am thinking about you and hoping this turns out to be a false alarm. Be sure to keep us posted.

Take care,
__________________
Gerri
Dx: 11/23/05, Lumpectomy 12/12/05
Tumor 2.2 cm, Stage II, Grade 3, Sentinel Node biopsy negative
ER+ (30%) /PR+ (50%), HER2+++
AC X 4 dose dense, Taxol X 4 dose dense
Herceptin started with 2nd Taxol, given weekly until chemo done
then given every 3 weeks for one year ending on March 16, 2007
Radiation 30 treatments
Tamoxifen - 2 yrs (pre-menopausal)
May 2008 - Feb 2012 Femara
Aug 2008 - Feb 2012 Zometa every 6 months
March 2012 - Stop Femara, now Evista for bone strengthening
**********
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back and realize they were the big things.
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Old 10-10-2010, 07:45 AM   #11
PinkGirl
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Re: Liver Enzyme ?

Thanks Barbara and GerriGirl
Everything sort of happened out of order. I had a physical
examination from my onc. She knew that I had a bad cold.
Then I went home (5 hours away) and I rec'd a phone call
the next day that my blood work showed 'elevated' liver
enzymes. I don't know how high they are. I talked to my
onc on the phone and she didn't say anything about my cold ...
said she wanted to do the ultra sound.... said we were being
cautious ... not to worry etc. etc.
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PinkGirl

Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

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Old 10-10-2010, 09:42 AM   #12
Gerri
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Re: Liver Enzyme ?

5 hour drive Pinkie? Wow! Since your onc didn't realize you had a bad cold maybe you could repeat the test (assuming you can do so locally) before you have the ultra sound. Just a thought...
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Gerri
Dx: 11/23/05, Lumpectomy 12/12/05
Tumor 2.2 cm, Stage II, Grade 3, Sentinel Node biopsy negative
ER+ (30%) /PR+ (50%), HER2+++
AC X 4 dose dense, Taxol X 4 dose dense
Herceptin started with 2nd Taxol, given weekly until chemo done
then given every 3 weeks for one year ending on March 16, 2007
Radiation 30 treatments
Tamoxifen - 2 yrs (pre-menopausal)
May 2008 - Feb 2012 Femara
Aug 2008 - Feb 2012 Zometa every 6 months
March 2012 - Stop Femara, now Evista for bone strengthening
**********
Enjoy the little things, for one day you may look
back and realize they were the big things.
- Robert Brault
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Old 10-10-2010, 10:58 AM   #13
PinkGirl
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Re: Liver Enzyme ?


I will eventually have the blood test again. Unfortunately, I have a killer cold that doesn't want to go away so I'll have to wait awhile.

Yes Gerri, a 5 hour drive one-way ... but that puts me in civilization ... the land of shopping malls, casinos and spray cheese. Hubby and I always make it a 3 day mini-vacation ... shop/gamble/fine dining at Pizza Hut, Burger King etc ....
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PinkGirl

Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

My Photo Album
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Old 10-10-2010, 12:59 PM   #14
fauxgypsy
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Re: Liver Enzyme ?

I'll be thinking of you. Hope that nasty cold gets better too.

Leslie
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In the world of destiny, there are no statistics.
Jan. 26- mammogram and ultrasound- suspicious lump
Mid-February- lumpectomy, infiltrating ductal carcinoma ~4.5 cm and a 1 cm DCIS, did not get clear margins, did not check lymph nodes
ER+/PR+, her2 +++, nuclear grade 3 of 3
February 20-PET scan showed something on liver. No biopsy.
March- Started carboplatin, herceptin, taxol on a four week cycle
May 3- Pet scan, with intent to do a biopsy, found nothing, liver or breast- no biopsy because there is nothing to biopsy
June 21- new onc, very concerned that there had been no biopsy,
June 18th-CAT scan, bone scan-negative
August 7th - Brain MRI-negative
August 9th- mastectomy, all pathology negative
January 2008 still NED! New oncologist -herceptin for full year after chemo- until July, and tamoxifen---negative scans since May '07
July 2008-Finished Herceptin!
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Old 10-10-2010, 01:08 PM   #15
Sheila
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Re: Liver Enzyme ?

Pinkie
So did you overindulge on the spray cheese before the tests? My liver enzymes have been off from meds, illness etc...I would get them tested again after the cold...and by the way, how about something to get you over that...you may have started with a virus but gone into a secondary infection...

Thinkin of you...I know everthing will be fine Pink!
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is fighting some kind of battle."



Hugs & Blessings
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Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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Old 10-10-2010, 04:24 PM   #16
chrisy
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Re: Liver Enzyme ?

Ha ha Sheila that must be it!

Liver enzymes can fluctuate due to a bunch of different things. Including tylenol - which makes me wonder of you've been taking stuff for your cold which might have that.

My husband had "elevated liver enzymes" - it was so little compared to what mine are from the TDM1 that I almost wanted to spit on the results. He had them retested and they were fine.

Probably nothing, but if you've been having ANY meds, that can affect things.
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 10-10-2010, 06:10 PM   #17
Sandra in GA
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Re: Liver Enzyme ?

This past May I had a little scare. My emzymes were slightly elevated - 5 points above the top normal. I didn't think anything about it, but my onc did. he scared the beejeebies out of me. After asking if I was taking Tylenol and my telling him "no", he said he wanted to see me in a month and do scans. Then he changed that and said, "Let's make it two months. That way if something is there, it will give it time to grow."

That shook me up. I very rarely have a glass of wine and could not think of what could be causing this. As soon as I got home, I started researching what is processed in the liver. All vitamins are. I learned that vitamin A, E, and D could especially cause increases in liver enzymes. I was taking a multivitamin along with 5,000 units of vit D for my bones. I stopped all vits and when I went back all the scans were clear plus my enzymes had dropped in half.

Pink girl, could it be your vitamins?
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Surgery: 8/14/08 Bilateral mastectomy; tumor left breast, node dissection; right prophylactic with expanders: 1/12/10 latisimuss dorsi flap on left side: 9/22/10 implants in
Pathology Report: ER/PR-; HER2+ (3+); Grade 3, StageIII; 3cm tumor plus 21/21 lymph nodes positive; 5cm DCIS
Chemo: A/C; Taxol/Herceptin/Tykerb; phase II study at Mayo adding Tykerb for early stage
Radiation: 25 rads
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Old 10-10-2010, 06:20 PM   #18
Gerri
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Re: Liver Enzyme ?

Pink,

You had me at shopping. Go forth and spend - nothing feels better than something new to wear...for me anyway...
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Gerri
Dx: 11/23/05, Lumpectomy 12/12/05
Tumor 2.2 cm, Stage II, Grade 3, Sentinel Node biopsy negative
ER+ (30%) /PR+ (50%), HER2+++
AC X 4 dose dense, Taxol X 4 dose dense
Herceptin started with 2nd Taxol, given weekly until chemo done
then given every 3 weeks for one year ending on March 16, 2007
Radiation 30 treatments
Tamoxifen - 2 yrs (pre-menopausal)
May 2008 - Feb 2012 Femara
Aug 2008 - Feb 2012 Zometa every 6 months
March 2012 - Stop Femara, now Evista for bone strengthening
**********
Enjoy the little things, for one day you may look
back and realize they were the big things.
- Robert Brault
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Old 10-11-2010, 09:25 AM   #19
PinkGirl
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Re: Liver Enzyme ?

No, no, no ..... no vitamins, no tylenol, no spray cheese.

Now I'm starting to get worried. I can't think of anything I did
to cause this.
__________________
PinkGirl

Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

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Old 10-11-2010, 10:06 AM   #20
Jackie07
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Re: Liver Enzyme ?

Pink,

Here's a link to the Merck Manual on the subject.

http://www.merckandcoinc.net/mmpe/se...23/ch023b.html

As you can see, there are many possible benigh reasons for the elevation(fatty food, high protein...) I remember the feeling when I was getting checked out for the irritation in my liver area. It turned out to be 'hepatic hemangioma'. But before we got the result, I was 'so' sure that I'd had liver met.

The wait is always stressful. Just wanted to let you know I am thinking of you and hope that everything turns out good.
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