I-SPY 2 trial qualifies neratinib for HER2-positive breast cancer

[News]

In an innovative clinical trial led by UC San Francisco, the experimental drug neratinib along with standard chemotherapy was found to be a beneficial treatment for some women with newly diagnosed, high-risk breast cancer.

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['lizbeth]

What are MP+ tumors? Anyone?

This is better, but where are the studies that show personalized treatment instead of randomized?

If everyone thinks they are getting the best treatment it negates the placebo effect.

At least it gets drugs approved for some, but we are still shooting at cancer with shotguns instead of rifles.

[donocco]

Elizabeth

I looked up MP plus breast cancer. I think MP stands for matrix producing. Im not a pathologist (Im a pharmacist) so I didn't fully understand the MP thing but basically it seems tat breast cancer cells can transform into connective tissues like cells.

Anyway the Matrix forming breast cancers are more aggressive than normal and it seems Matrix producing breast cancers are very often triple negative.

Hope this helps a bit.A pathologist can explain it better

Paul