Mdx-010

wennydog · 09-12-2007, 10:12 AM

Has anyone heard of Ipilimumab? It is also called MDX-010 and is produced by a company called Medarex. It is for Melanoma but a completed phase 2 study on breast cancer was also done. I have not been able to find any results on this drug and breast cancer. There seems to be a lot of excitement in the melanoma community about MDX-010.

About MDX-010
MDX-010 is a fully human antibody against human CTLA-4, a molecule on T
cells that is believed to be responsible for suppressing the immune response.
MDX-010 is in clinical studies to investigate its potential to enable the
immune systems of cancer patients to fight tumors. MDX-010 is currently in a
Phase III clinical trial for metastatic melanoma and in multiple Phase II
clinical trials to investigate the product's potential activity in other tumor
types. The potential use of MDX-010 outside oncology is also being explored.

There is a compassionate use trial starting for melanoma and I was interested in contacting Bristol Myers /Squibb to see if they would do a single patient trial for Pat but I wanted to know how the trial went using it for breast cancer. Anyone with info , Thanks Donna

Pat Bailey 55 yo
2001 DX DCIS, mastectomy & reconn
2003 dx mets to lungs, double thoracotomy for bx, herceptin, navelbene,carbpl,
2005chest wall reoccurrance, rads, repeat herceptin, navelbene,carbopl
2006more mets to chest wall, axillary and rt neck lymph system, Taxotere, herceptin
x 2 treatments, inflammtion to lungs,pneumonia, stop taxotere , rads
2007disease progression to small intestine, rt. axilla, lungs,epirub,5FU,cytoxan x 2 tx
disease halted but counts so low and so weak that chemo stopped.
July2007 disease progression, given 3 weeks to live. Began herceptin, doxorubicin
2 weeks later ready to leave hopitaland ambulatory with assistance. 1 week at home then
signs of lymphedema and epidermal skin rash returning. #2 dose of doxil given with no response.
Gemzar started while back in hospital with slow positive response. Back home but terrible weakness and stomatitis.
Stop doxil. Start Gemzar, tykerb and herceptin on 8/21/07
9/12/07 Diarrhea too devestating, Tykerb stopped. Gemzar every week still keeping cancer signs away.