more on how fatigue after breast cancer treatment comes about--dec response2 cortisol

Lani · 10-02-2006, 03:48 PM

Brain Behav Immun. 2006 Sep 26; [Epub ahead of print] Links
Inflammatory responses to psychological stress in fatigued breast cancer survivors: Relationship to glucocorticoids.

Bower JE,
Ganz PA,
Aziz N,
Olmstead R,
Irwin MR,
Cole SW.
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, 300 UCLA Medical Plaza, Room 3306, Box 957076 Los Angeles, CA 90095-7076, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, USA; Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center at UCLA, USA.
Fatigue is a common problem following cancer treatment and our previous studies suggest that a chronic inflammatory process might contribute to cancer-related fatigue. However, immune responses to challenge have not yet been evaluated among individuals with cancer-related fatigue, and it is not known what mechanisms drive increased levels of inflammatory markers in fatigued cancer survivors. We have previously reported that fatigued breast cancer survivors show a blunted cortisol response to an experimental psychological stressor. In this report, we focus on inflammatory responses to this stressor and their relationship to circulating glucocorticoids and cellular sensitivity to glucocorticoid inhibition. Relative to non-fatigued control survivors, participants experiencing persistent fatigue showed significantly greater increases in LPS-stimulated production of IL-1beta and IL-6 following the stressor (GroupxTime interaction: p<.05). Fatigued participants did not show any difference in cellular sensitivity to cortisol inhibition of cytokine production, but they did show significantly less salivary cortisol increase in the aftermath of the stressor. Moreover, blunted cortisol responses were associated with significantly increased production of IL-6 in response to LPS stimulation (p<.05). These data provide further evidence of enhanced inflammatory processes in fatigued breast cancer survivors and suggest that these processes may stem in part from decreased glucocorticoid response to stress.
PMID: 17008048 [PubMed - as supplied by publisher]

R.B. · 10-03-2006, 08:23 AM

There are quite a lot of suggestions linking fatigue higer IL6 with lack of omega three / excess six.

I think I previously posted another link on inflamatory factors and fatigue.

Interesting.

Thanks for the post.