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Old 08-31-2006, 10:35 AM   #1
mindersue
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Blood Counts and Herceptin

I'm currently in my 8th month of receiving Herceptin. Finished chemo last May and radiation in early August. I started taking Aromasin two weeks ago. My blood counts are really low. Does anybody have any experience with low blood counts AFTER chemo?

Dr. took my off Aromasin for a week. I'll get rechecked then, if not better, I'll get a bone marrow test. I really don't think it's the Aromasin, but I could be wrong.

THANKS!
Mindy
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Old 08-31-2006, 03:54 PM   #2
tousled1
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I started Herceptin in June of this year and have had to have Procrit shots almost every week due to low blood count.
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Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 08-31-2006, 07:19 PM   #3
mindersue
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How about Aromasin and low blood counts, or radiation and low blood counts?

Grasping for straws,

Mindy
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Old 08-31-2006, 07:52 PM   #4
tousled1
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I'm not on Aromasin so I can't say how it affects blood counts. When I was on A/C and then Taxatore my red and white counts were always low. Then I was getting shots of Neulasta the day after chemo and Procrit the day of chemo.
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 08-31-2006, 08:34 PM   #5
chrisy
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Mindy,
It can take some time for your blood counts to rebound after chemo. Are they continuing to drop on Aromasin/Herceptin or just not getting better? I've no experience with Aromasin, but have been on Herceptin alone for a year and a half and my blood counts have stayed pretty good.
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 08-31-2006, 09:15 PM   #6
mindersue
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Thanks for the responses. My counts were low in July and lower today, after being on Aromasin for 2 weeks. My pharmacist friend said that Aromasin can cause counts to drop (about 20% of the time), as well as radiation.

I have to admit it freaked me out a little bit. : ) It just seems like they're going the wrong way. I'll wait and see how they come back in a week.

Thanks again, you guys are great!
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Old 09-01-2006, 01:27 PM   #7
Sherryg683
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I have been finished with chemo since April and radiation since June, I've been on Herceptin every week. I still drag butt. Yesterday after getting my scan results I decided to take a look at my blood counts, I just figured they would be fine since it's been months since heavy chemo. My white counts were very low and my red counts were right at the mininum. I don't know if it's the Herceptin or just my body hasn't recooped, but that explains my feeling sluggish. I take tons of vitamins and supplements too, so I thought my counts would be fine. My Oncologist isn't too concerned with it, but I will keep an eye on it..sherry
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Old 09-01-2006, 01:32 PM   #8
Barbara
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Blood Counts

Hi:

I have been on Herceptin only for two years and my red and white counts are both below normal. They offer me Aranesp to boost my red cells but I have refused this medicine. Approximately 2-3% of patients are affected by Herceptin alone. Until you finish Herceptin it is difficult to determine if the cause is bone marrow suppression from the original chemo or Herceptin.

Barbara
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Old 09-01-2006, 02:41 PM   #9
Rupali
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One of the things you need to do is to check for Magnesium and get in touch with an integrative medicine practicioner. Mine were low and they found I had a deficiency of Magnesium. I was put on Magnesium pills and evrything became ok.
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Old 09-01-2006, 11:36 PM   #10
Chelee
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Mindy, I had just asked my infusion nurse about my red count staying a "little" low. Nothing to worry about...but I thought it would be back to normal by now? Last chemo was June 12th, however I still do weekly herceptin.

She said it can take up to six months for your counts to get back to normal. I asked if she thought it was the herceptin doing it? She had a bout with cancer 10 years ago and did chemo herself and she said her counts did not get back to normal till around 5 or 6 months.

I have heard about people having low counts after radiation. I would think it would take a little longer since your body has been put through so much. First chemo, then rads recently. Thats pretty hard on the body. Keep us updated and let us know if taking you off the Aromasin made any difference? (Although I wouldn't think it would..but then there is so much I don't know about these drugs? Anything is possible.) Hang in there!

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 09-02-2006, 08:57 PM   #11
Bev
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I went back to normal after chemo. Rads can affect counts as well. I'm sure ypur docs will have advice, but things should pick up after rads. Good luck. BB
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