Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluorine

[R.B.]

IS THERE A ROLE FOR IODINE IN
BREAST DISEASES?
Sebastiano Venturi, Servizio di Igiene, ASL n.1, Regione Marche; Pennabilli (Pesaro), Italy

Published in "THE BREAST" , Vol.10, Number 5, 2001, p 379-382,

Abstracts of this have been previously referred; this is a link to a PDF of the paper.

https://scholar.google.com/scholar?h...DISEASES&btnG=

[R.B.]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327366/

Abstract - full free paper at link - one important factor of several I suspect


"Changes in Dietary Iodine Explains Increasing Incidence of Breast Cancer with Distant Involvement in Young Women"

"In conclusion, dietary iodine insufficiency represents a plausible explanation for the increasing incidence of breast cancer in young women with distant metastasis. In view of the established reduction in iodine levels in US women of childbearing age since the mid 70s, this group would be most vulnerable to increased breast cancer risk. The increased sensitivity of breast tissue to estradiol induced proliferative changes in the setting of dietary iodine insufficiency, provides a plausible mechanistic explanation for the increasing incidence of breast cancer with distant involvement in this age group. Based on the importance of iodine in thyroid and breast health, fetal brain development, as well as deficits in nutritional trends among younger women, iodine testing and management may be considered as a potentially important aspect for clinical practice."

[R.B.]

As usual more research required!


https://journals.lww.com/oncology-ti...Cancer.13.aspx

"How Molecular Iodine Attacks Breast Cancer"
Oncology Times: December 25, 2016 - Volume 38 - Issue 24 - p 34
doi: 10.1097/01.COT.0000511599.52147.f1

Abstract

"Researchers have elucidated the mechanism of action for molecular iodine to determine how it helps protect women from fibrocystic breast condition (FBC) and confirm how it attacks breast cancer.

"Numerous studies have previously suggested iodine supplementation can promote breast health, but none had determined precisely how it worked with FBC cells. Investigators sought to identify the specific MOA that made molecular iodine effective."

"The breast cancer study focused on two common breast cancer subtypes using well-established breast cancer cell lines, MCF7 (a luminal A subtype) and MDA-MB231 (a triple-negative subtype). Cells were treated with molecular iodine at various concentrations to measure proliferation and cell death. This was subsequently followed by gene expression analysis of key important molecular markers, which are primarily responsible for cell growth and apoptosis. Primary human mammary epithelial cells derived from a healthy female donor were used as an internal control."

"Data from these studies indicated that molecular iodine has potent inhibitory effects on cell growth in both breast cancer and FBC (fibrocystic breast condition) The data also showed a dramatic increase in cell death in breast cancer cell lines used in the study and in cells derived from fibrocystic breast tissue."

"“Although several studies have, through the years, shown that molecular iodine can promote breast health and protect women from fibrocystic breast condition and potentially cancer, no one has ever identified molecular iodine's mechanism of action in fibrocystic breast condition,” said Usha Nagavarapu, PhD, study director and principal investigator of the project. “The pre-clinical investigations confirm the MOA and give the medical community reason to revisit the earlier research for clues on how best to use molecular iodine to treat and protect women.”"