http://www.therapeuticsdaily.com/new...e&channelID=28
New antibody may help treat ovarian, breast cancer
Researchers at East Carolina University (ECU) have developed a monoclonal antibody that could play a vital role in treating the most common form of ovarian cancer, breast cancer and other cancers.
They are working with two major drug firms, ImmunoGen Inc. and sanofi-aventis, that have the expertise in formulating antibodies into cancer therapies and taking them to clinical trials in humans.
Dr. Anne Kellogg, an associate professor of pathology and laboratory medicine at the Brody School of Medicine at ECU, created the antibody, called DS-6, that attaches to cancer cells.
DS-6 will serve as a delivery vehicle for a highly potent cell-killing agent developed by ImmunoGen specifically for delivery to cancer cells by antibodies.
The antibody latches on to tumour cells and enables the whole compound, the antibody and the attached cell-killing agent, to enter the cancer cell.
Once inside, the cell-killing agent becomes activated and kills the tumour cell as it divides.
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