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07-26-2011, 02:33 AM
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#1
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Senior Member
Join Date: Feb 2007
Location: Paris, France
Posts: 858
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Navelbine and Ears
Hello to all. I am having a hard time with Navelbine. Until now it was either constipation, diarrhea, nausea, vomiting, pains and neuropathy. My onc lowered the dose by 30% the last 2 weeks. I had Zometa for the first time last week with the Navelbine. I wanted to hold out at least 6 months. But all of a sudden my both ears are like plugged, as if I came out of the water. I am in a fog. My hearing is not as good. I am frightened. It has been 5 days now. I have no ringing or pain. Did this happen to anybody? Is it reversible? I did not read this toxicity on the list of side effects. Should I stop Navelbine?
Michka
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07-26-2011, 05:07 AM
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#2
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Senior Member
Join Date: Sep 2005
Location: MN
Posts: 731
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Re: Navelbine and Ears
Have you been to a doctor? Perhaps it's not chemo related but an ear infection going on.
__________________
Pam
6/01 IBC er+ her2+stage IIIb; mastecomy
7/01 AC, taxol; radiation
2/02 tamoxifen
9/02 stage IV bone mets femara
1/03 taxotere/herceptin/aredia
6/03 herceptin, aredia & faslodex
1/04 navelbine, herceptin, aredia
2/05 herceptin/aredia
7/05 xeloda/herceptin/aredia
3/07 xeloda/tykerb/aredia
5/08 taxol/avastin/aredia
2/09 gemzar/herceptin/zometa
7/09 Taxol/Carbo/Herceptin, zometa
10/09 navelbine/herceptin & zometa
2/10 herceptin & tykerb & zometa
4/10 add xeloda &aromasin
10/10 dx with dermatomyiositis triggered by cancer
11/10 restart herceptin, tykerb, zometa
12/10 surgery-place rod in R femur to stabilize bone
1/11 radiation to R femur - 20 tx
2/11 2nd surgery - rod in Left femur
2/11 tx eribulen -- suspended dx brain mets
3/11 brain mets wbr 20 tx
4/11 halaven; discontine 8/11 not working
8/11 radiation to left femur 20 tx'
8-9/11 rad to lower spine
9/11 abraxane/herceptin/zometa
9/12 xeloda/herceptin/zometa
12/12 ablation of liver
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07-26-2011, 07:20 AM
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#3
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Senior Member
Join Date: May 2010
Location: Ireland
Posts: 271
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Re: Navelbine and Ears
Michka, I got the same trouble with my ears (one worse than the other). I blamed the Zometa. Oncologist checked my ears, small area of inflammation and he recommended paracetamol, it cleared it up. Hope it works for you too. Best wishes.
__________________
Delaney, dx 2008 lumpectomy,mastectomy,a/c,paxitaxol, tyverb 1 yr.
dx 2010 mets lymph nodes, skin, lung. start taxotere/herceptin.
Stopped taxtere/herceptin, now on tyverb/xeloda.
Lung mets shrinking.
Back on Herceptin with T/X. Partial response.
Skin mets progressing. Radiation scheduled mid february 2011.
Spot found on hip - radiation to hip beginning mid February 2011.
Now trying Gemzar/Tyverb/Herceptin and Zometa.
CT scan Feb 2011 - lung clear!
Brain mets (specks) - radiation mid Feb.
Brain Scan June'11 - Clear
CT Scan June'11 - Good - skin met active - watch and wait.
Surgery to remove skin met. Surgery to back 2012, four titanium rods inserted. Skin mets reappear. On Navelbine, not working. 4 week washout, start Myocet for skin and lung mets August 2012. Brain scan clear despte intermittent blurry vision (something hiding? Am suspicious but hopeful. )On we go, glad to be here.
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07-26-2011, 07:58 AM
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#4
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Senior Member
Join Date: Feb 2007
Location: Paris, France
Posts: 858
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Re: Navelbine and Ears
Thank you for reassuring me. I am silly! Since I have no pain in the ears and no cold I didn't even think it could be an infection. I took paracetamol but it made no difference. I'll have that checked.... and I have to stop imagining the worse. Michka
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07-27-2011, 07:37 AM
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#5
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Senior Member
Join Date: Jan 2010
Posts: 170
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Re: Navelbine and Ears
Bon Jour Michka,
I had some problems with my ears and discovered it was from taking nexium for acid reflux. When you take it long enough, it inhibits your body's ability to absorb vitamin B12. I stopped taking it and started taking B12 and now my ears are fine. Not sure if it will help you, but worth a thought. I also had severe bone pain and fatigue for a week after my first infusion of Zometa. It got easier the longer I was on it. It has also done a number on my kidneys, so do be aware to drink lots of fluids in the 24 hours after your infusion.
On another note, my daughter is moving to Paris in August with her job. She works for Arevia in Wash. D.C. and just took a job in Paris. I hope to be able to afford a trip to visit her sometime soon.
Take care and remember we ALL have our silly moments of fear. You are not alone.
Emelie
__________________
Nov. 2006-IDC with Her2 +++
A/C for 3 rounds
Dec. 2006- Herceptin and Taxotere
March 2007-MRM with 8 of 14 lymph node involvement
May 2007-36 Rads
Sept. 2007- Stopped Herceptin
Jan. 2010- CT scan shows enlarged lymph nodes in sternum and lung involvement
Feb. 2010-PET scan shows mets to liver, lung, lymph nodes and bone
Feb. 2010- Started Herceptin/Taxol and Zometa
April 2010-PET scan clear. Herceptin and Zometa
June 2010- Stopped Herceptin continue Zometa and still NED
August 2010-Back on Herceptin and Zometa every 3 weeks
August 13, 2010- Had another port placed
August 24, 2010- PET scan clear. Herceptin and Zometa every three weeks
Nov. 2010-PET scan clear
Feb. 2011-Brain MRI clear
March 2011- PET scan clear
May 2011- PET scan clear
Sept. 2011- PET, Mammo, Bone Scan all clear- Herceptin only
March 2012-Recurrence in lungs and tumor around pota hepatis artery. Added Navelbine to herceptin
April 2012- Entered palliative care
June 5, 2012-Entered hospice care
Planning my memorial
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07-30-2011, 06:30 AM
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#6
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Re: Navelbine and Ears
Michka
Hoping the ear issues have cleared and things are looking up for you. In this cancer world we live in, we have a right to be scared, it comes with the territory...
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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