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Old 10-09-2009, 10:19 AM   #1
Lani
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Join Date: Mar 2006
Posts: 4,778
now bean counters looking at radiation therapy vs cyberknife

in this case for bone mets, but hopefully not for brain mets in the future

Efficacy, safety and quality of life need to be weighed in

2009 BC SYMPOSIUM: ABSTRACT #152: Cost comparisons for a course of radiation therapy for painful bone metastases from breast cancer using different technologies and fraction schema
[American Society of Clinical Oncology]
Background: Providers are faced with an array of options when sending their patients (pts) with painful bone metastases (PBM) for treatment (Rx) with radiation (RT). It has been shown (Hartsell et al. & others) that a single fraction(fx) of RT has equal efficacy to a 10 fx course with respect to pain relief & freedom from narcotic usage at 3 months. Nevertheless, some believe that delivery of a higher dose, as facilitated by fractionation and conformal Rx, may allow for greater long term palliation in select subgroups, such as pts with long life expectancies or radioresistant histologies. Different delivery systems & techniques—conventional RT (XRT), stereotactic radiosurgery (SRS), Cyberknife (CBK), & others- can be used, but are associated with different amounts of time involved by providers & pts alike, as well as different levels of reimbursement (reim).
Methods: CPT codes and Medicare reim were reviewed for seven potential scenarios for treatment of PBM. Freestanding (Fstd) estimate and Outpatient(OP) hospital estimate are based on WPS Medicare Michigan Locality 01 2009 and 2009 APC national reim rates. Using CPT codes that would be typically associated with a course of Rx, seven scenarios were reviewed: single fx and four fx courses with CBK in Fstd center and OP hospital settings, four fx course of SRS, and one and ten fx courses of XRT in an OP hospital setting.
Results: The results of the analysis is reported in the table.
Conclusions: There is a wide range of expense associated with the delivery of palliative RT for PBM, ranging from $1700 for a single fx of XRT delivered in an OP hospital setting, to $16118 for four fx of CBK in an OP hospital setting. This may have implications on the choice of modality for RT delivery for some providers and pts alike. Further research should examine the relative efficacy of the varied approaches commonly utilized for Rx of PBM to determine whether more expensive options are relatively cost-effective in any pt populations.
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Old 10-09-2009, 03:21 PM   #2
hutchibk
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Re: now bean counters looking at radiation therapy vs cyberknife

3D conformal IMRT sterotactic radiosurgery (Varian brand is the machine that my rads onc uses) is equally as adept, if not superior, for treating many bone and brain mets as Cyber, so efficacy is a non-issue and safety is not any different with IMRT. Cyberknife is just a brand name of the same technology, but the machine operates a little differently. Varian type IMRT srs is not as expensive as Cyber.

As far as quality of life, with Cyberknife, one of the problems is that some patients might not be able to tolerate lying on the table for the duration of treatment (> 1 hour). IMRT, like I have had for my brain mets, is a few consecutive days of 10-15 minute treatments.

Cyberknife, Gammaknife and Proton Beam all have very sexy names that draw people into believing they are automatically superior treatment options, which is not necessarily true.
__________________
Brenda

NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."

Last edited by hutchibk; 10-09-2009 at 03:29 PM..
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Old 10-09-2009, 03:31 PM   #3
Lani
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Re: now bean counters looking at radiation therapy vs cyberknife

3D conformal IMRT sterotactic radiosurgery (Varian brand is the machine that my rads onc uses) is equally as adept for treating bone and brain mets as Cyber, so efficacy is a non-issue and safety is not any different with IMRT. Cyberknife is just a brand name of the same technology, but the machine operates a little differently. Varian type IMRT srs is not as expensive as Cyber.

can you cite articles on each of these statements?

Also perhaps needing to be considered is the possibility that the radiation targetting may not be as exact when there are several different sessions as
despite masks,beanbags, etc there may and probably are differences in postioning and therefore the area targeted from day to day
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Old 10-09-2009, 05:11 PM   #4
hutchibk
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Posts: 3,519
Re: now bean counters looking at radiation therapy vs cyberknife

I can't link my rads onc's brain to this forum, but he is a physicist who is also a rads onc, who has worked with both brands (Cyber and Varian) and has chosen Varian technology as the future for his practice, his patients, and for his experience of superiority with the brand. I will look for backup in articles, but I take my genius doctor at his word. *also you can also google for yourself*

I am CTed on the table for perfect measurement and precise targeting everyday when I get rads. ("There probably are differences in positioning..." - hate to be a stickler, but "probably" sounds like a subjective opinion.)

Also, I have read similar discussion of the technologies online, I particularly remember a doctor/medical student forum that touted the positives of 3D conformal IMRT vs Cyber.
__________________
Brenda

NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."

Last edited by hutchibk; 10-09-2009 at 05:26 PM..
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