Covid vaccines and cancer patients

[Nguyen]

Not sure how I stumbled across the info that NSAOD pain killer impacts immune respond from vaccine. I thought I saw something similar on CDC, but for some strange reason, couldn't find it again yet. An ultra short summary of the two pubmed articles below is:

NSAID class pain killer (anti inflammatory) block the Cox-2 pathway and in turn blocks the final transformation of B lymphocytes to become plasma producing cells which produce antibody. Reduction of antibody implies a weak immune respond.

Incidentally, lots of conventional drugs are cox2 inhibitor. Natural anti inflammatory substance such as tumeric/curcurmin also is a cox2 inhibitor.

Nguyen

From CA Orange County:

http://www.ucihealth.org/covid-19/co...0the%20vaccine.

“Q. Should I take Tylenol or Motrin before my vaccination?
A. If you regularly take aspirin, acetaminophen (e.g., Tylenol) and ibuprofen (e.g., Motrin, Advil) for other medical conditions, continue to do so as directed by your physician or as needed. Otherwise, do not pre-medicate.
Taking over-the-counter medications such as acetaminophen and ibuprofen before receiving a vaccine may reduce its ability to work and blunt your immune response to the vaccine. After the vaccination, don’t hesitate to take an over-the-counter medication if you have symptoms that make you uncomfortable.”
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https://www.urmc.rochester.edu/news/...lenol-for-mild

“…Unless your health care provider tells you otherwise, it’s best not to take pain relievers one or two days before the flu vaccine and for a week afterward,” said David J. Topham, Ph.D., a study author and professor in the Center for Vaccine Biology and Immunology at URMC.

What about low-dose aspirin? Individuals who take aspirin for cardiovascular or vascular disease should talk to their doctors before stopping even low-dose aspirin. And people who take medications such as Celebrex for arthritis or other chronic pain also should consult their physicians…

The use of NSAIDs may adversely influence the efficacy of vaccines, especially in the immunocompromised, elderly and when vaccines are weakly immunogenic…”

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I believe the research below are the reference science for above guide lines.

https://pubmed.ncbi.nlm.nih.gov/19941994/

https://pubmed.ncbi.nlm.nih.gov/20050331/