Cannabinoid receptors – main ligands are Omega 3 and 6 derivatives, not hemp products

[R.B.]

As above blocking / altering Omega 6 endogneous cannabinoid activity, and intervening in the Omega 3 : 6 cannabinoid messaging metabolic control see-saw in pregnancy is going to have physiological effect.

What is the effect of cannabinoids in CBD - we simply do not know - but we do know plant based cannabinoids may well impact brain development and later physiology - and THC in cannabis likely does - further the body is so complex - it is unlikely that interventions with non-endogenous plant based cannabinoids outcomes in pregnancy will be overall generally beneficial.

Given we do not have the answers, surely caution should be the way to go, and mothers should be made fully aware of the issues surrounding CBD, more particularly cannabinoids in pregnancy, breast feeding and ealry rearing, and which arguably they are not at the moment.




Prenatal Exposure to Cannabis Affects the Developing Brain
Children born to moms who smoked or ingested marijuana during pregnancy suffer higher rates of depression, hyperactivity, and inattention.

https://www.the-scientist.com/featur...ng-brain-65230

"When marijuana is ingested or smoked during pregnancy, exogenous cannabinoids enter the blood and cross easily through the pla*cental barrier."

"To date, the three largest longitudinal studies of the children of women who smoked marijuana once a week or more during their pregnancies have identified remarkably consistent outcomes during early development and through young adulthood. In infants, these include increased impulsivity, hyperactivity, and delinquent behaviors, as well as memory dysfunction and decreased IQ scores. During adolescence and early adulthood, fetal cannabis exposure has been linked to persistent reduction in memory and concentration, higher rates of drug use, and an increased incidence of hyperactivity, signs of depression, and psychotic and schizophrenic-like symptoms. These mental health issues are further evidenced by increased reports from both parents and schoolteachers of problematic behavior and delinquency in cannabis-exposed kids."