Cannabinoid receptors – main ligands are Omega 3 and 6 derivatives, not hemp products

[R.B.]

This gives a hint of the importance of cannabinoid receptors - as above, many of the reported beneficial effects of hemp derived cannabinoids could be a reflection of low levels of Omega 3 and excess Omega 6s in peoples' diets.

Yes complicated and of course this very much is a generality - but vendors are not saying sort out your Omega 3 - 6 profile / wider diet first/as well, and see if that works, they are instead offering hemp products, in part because the basic mechanisms are not widely appreciated..

Yes, and as above, hemp products have a heap of uses, including for making hemp fiber products, but hemp oil products do not address all the issues that arise from Omega 3 - 6 imbalances - they only 'block' the CB receptors - normally filled by Omega 3s and 6s derivatives; and that is only one of many important roles of Omega 3s and 6s - there are massive families of bio-active products of both Omega 3 and 6, and lack of Omega 3 and excess of Omega 6s have a host of biological effects - further hemp oil may contain a wider range of other factors of uncertain effect as highlighted by the Harvard commentary above.

CBD indeed likely has useful as yet very imperfectly understood pharmacological roles, but as with other palliative products, should we not be sorting out more long-term, underlying, causes of the rising incidence of non-communicable oxidative and inflammatory related conditions?


Docosahexaenoyl ethanolamide (DHEA) is an Omega 3 endocannabinoid

https://www.caymanchem.com/product/10007534

"Docosahexaenoic Acid (DHA) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. Docosahexaenoyl ethanolamide (DHEA) is the ethanolamine amide of DHA that has been detected in both brain and retina at concentrations similar to those for arachidonoyl ethanolamide (AEA).1,2 A 9.5 fold increase of DHEA was observed in brain lipid extracts from piglets fed a diet supplemented with docosahexaenoic acid (DHA) compared to a control diet without DHA.3 DHEA binds to the rat brain CB1 receptor with a Ki of 324 nM, which is approximately 10-fold higher than the Ki for AEA.4 DHEA inhibits shaker-related voltage-gated potassium channels in brain slightly better than AEA, with an IC50 of 1.5 µM.5"