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Old 02-27-2016, 11:00 AM   #1
broccoli
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Re: Do you take Metformin?
I've just heard from a friend on the Metformin trial who had TNBC that all ER-/PR- patients are being dropped from the trial because the latest analysis of the data has shown that Metformin has no effect on recurrence rates for that group.

I haven't yet heard from my study coordinator (my cancer was ER-/PR-/HER2+) but once I do I'll post back here.
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2012-Feb-29 D-Day: IDC ER-/PR- HER2+++ Grade 3, Stage 3 - several biopsy proven positive nodes
2012-Mar - July: Neoadjuvant FEC-D + Herceptin (6 rounds)
2012-Apr: DVT in arm that received chemo - put on LMW Heparin
2012-Apr: Port installed
2012-Sep-7: Lumpectomy + ALND - pCR with residual DCIS
2012-Oct: Switched from LMW Heparin to Warfarin
2012-Oct-Nov: 30 days of rads
2013-Jan: Entered Adjuvant Metformin trial (Metformin or placebo for 5 years)
2013-Jan: Switched from Warfarin to Xarelto
2013-Mar: First signs of lymphedema
2013-May-16: Last Herceptin (17 doses in total)
2013-Jun: Port removed and anticoagulants stopped
2014-Mar: Lymphedema worsened and became unresponsive to treatment
2015-Apr: Started PENTOCLO protocol to attempt to improve radiation fibrosis
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Old 02-27-2016, 11:03 AM   #2
sarah
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Re: Do you take Metformin?
that's disappointing. Did they test ER+ as well or not?
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Old 02-27-2016, 11:56 AM   #3
thinkpositive
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Re: Do you take Metformin?
Broccoli,

Thanks for the info. I'll be curious to see if they do infact decide that ER-/PR- folks are not helped by metformin. I appreciate your comment about posting back to this thread if you are contacted by the study coordinator.

Take care,
Brenda
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8/2013 Diagnosed IDC Left Breast ER-/PR-/HER2+ Stage 3C, DCIS ER+/PR+/HER2- Right Breast (54 yr)
8/2013 PET/CT scan shows mass in uterues and suprclavicular nodes
8/20/13 Begin 6 rounds TCH chemo, Perjeta added for rounds 4-6
9/2013 After 1st round of chemo, mass in neck and breast no longer able to feel
11/2013 Hysterectomy, mass from PET/CT scan not cancer (adenomylosis)
12/2013 Finished chemo
1/2014 Double mastectomy with chest expanders
1/2014 Pathology report from surgery and SNB show complete pathological response!
3/2014 Finish IMRT radiation
8/2014 Fat transfer to radiated breast
8/2014 Completed 1 yr of Herceptin
10/2014 exchange surgery expanders removed implants placed
6/2015 3D nipple and areola tattoos
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