The Brain Microenvironment
Why do we have brain mets? Because we have cancer cell lines with an affinity for the CNS space. It is protected from most chemotherapy medicines due to the
blood brain barrier. The observed saturation of drugs getting into the CSF is less that 1-5% depending on surrounding damage to the BBB from the tumor/craniotomy/rads. You can even request to have a lumber puncture done to see how much drug is getting in there. Anyone done that or had it offered?
The brain is also a glucose-rich environment, conditions to culture the very anaerobic conditions our cancers love to be in. Yes, you have cancer cells in your head eating bon-bons right now.
I removed reading how the afternoon cup of coffee boosts glucose and copper leveks in the brain which helps increase cognition in the afternoon. Sugar and copper -- wait aren't those both pro-inflammatory and pro-cancer? Yes. And it isn't discussed, particularly in light of a brain met diagnosis.
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