YES!!! It is here. Phase II vaccine trial for Her2 3+

['lizbeth]

Oh, so here is the one for you JayKay, and I quote:

The GP2 vaccine works in much the same way as the E75 vaccine. Like E75, the GP2 peptide is 9 amino acids long and binds to MHC class I molecules to stimulate CD8-positive T cells; thus, the vaccine works only in patients who are positive for HLA-A2 or HLA-A3. In contrast, the AE37 peptide, which is longer than the E75 and GP2 peptides, binds to MHC class II molecules and stimulates CD4-positive T cells, thereby eliciting a more robust immune response. Although MHC class II peptides can be HLA-restricted, AE37 is a promiscuous peptide, meaning that blood cells of almost any HLA type can present it. In addition, the AE37 peptide is paired with the Ii-Key protein, which enhances the presentation of the peptide to the immune system.

Somehow I find it very amusing that they chose the racy term "promiscuous peptide" for AE37 - for those who are HLA A2 negative. Not only is there something out there for you, and it isn't just your ordinary peptide,

[thinkpositive]

Lizbeth,

Thanks for your post. You are absolutely right. I'm very grateful to have achieved a pathological complete response. I should just focus more on that rather than on not being eligible for the trial. I appreciate the reminder.

Having the trial opened to other HER2 folks is huge!

Take care

[sandra85208]

Hi I hope you are well. I am in Minnesota. I was in a clinical trial in 2011. so far so good. But it has been a long a painful journey. Lots of surgery and depression, stuff like that.