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Old 09-13-2013, 12:05 PM   #1
Nancy L
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Join Date: Apr 2009
Location: La Quinta, Ca
Posts: 253
Re: How do you boost your platelets on Kadcyla

I highly recommend that you print the Genentech Kadcyla dosing and administration guide available on the internet. It gives the company's guidance about what should be done when various tests are not normal. For platelets, they recommend administration be held if platelets go below 50,000. I was also told this by two oncology offices where I received Kadcyla on the expanded access program. My platelet count started at 263000 and dropped to 68,000 after 11 treatments. They have remained in the 60,000 range ever since.

I am currently on a break because my T. Bilirubin went above 1.5. I have an excel spreadsheet to follow all the lab work and scans Genentech talks about in the guide. It is very helpful to discuss my concerns with my oncologist who knows little to nothing about this drug. I am the only one on it in this rather large oncology practice. He told me on my last visit that I should have been a doctor and I took that as a compliment.

Good luck with Kadcyla. I have found it to be a difficult drug and the idea of being on this for the rest of my life is frightening.
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Old 09-13-2013, 01:26 PM   #2
yanyan
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Join Date: Apr 2011
Posts: 403
Re: How do you boost your platelets on Kadcyla

Thx Nancy. My onco planned 6 cycles of Kadcyla for me. He didn't want to reduce the dosage but if my platelets don't get to 65,000, i will have a reduced dosage next week. The plan for me is rescan after the 6th infusion. If all affected areas in chestwall is gone, he would like to put me on maintenance drug. I have had non stop chemo for 2.5 years and i am finally planning to take medical leave in Oct. How are you doing on your treatment? 11 months must be tough ! If you are stable or NED, has your doctor talked about taking you off Kadcyla?
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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