T DM-1 Approved !!

fullofbeans · 02-26-2013, 04:05 AM

great news just great news!

KristinSchwick · 03-02-2013, 07:49 PM

Just wondering if anyone has gotten TDM-1 since its approval? My doc. has me scheduled to start it on Tuesday if my labs show my current therapy has run its course.

Also, just for discussion sake- I have heard that in order for cancer cells to get into your brain, your BBB must be compromised in some way, therefore- a large molecule like TDM1, may still be able to enter and circulate some in the brain. Anyone else heard this?

gdpawel · 03-03-2013, 01:09 AM

Joan

That you for the url link on Vogl's piece. He told Medscape Oncology that the data on Kadcyla (T-DM1) are not as clear as they should be. The study's control regimen (Tykerb and Xeloda) was "distinctly suboptimal" and not a standard of care, even though it is an FDA-approved treatment option in this setting. The 5.8 month difference in overall survival in the two study groups might have been inflated by this control regimen. He would have preferred to see the control patients also receive Herceptin, which he believes to be a necessary complement to Tykerb.

He went on to say that Kadcyla (T-DM1) does not meet the goals of a major advance, explaining that such an advance, in his opinion, must cure some patients, increase the rate of clinical complete remission, or produce a high rate of very long partial response.

This all should remind physicians that it is the good outcome of the patient not the therapy applied that constitute successful application of the healing arts. We must remember that the best medical care is not always the most expensive. We can still hope for a good outcome if you use all the available drugs at our disposal that best meet the needs of the patient. http://cancerfocus.org/forum/showthread.php?t=3768

Becky · 03-03-2013, 05:42 AM

Tykerb was paired with Xyloda because (I think) they wanted to test a regime where patients do not have to go to the cancer center for treatment. They are both pills that you can just take at home.

From friends and all the women on this board, Xyloda seems not to do much or last very long. Other chemos seem far more effective (taxanes etc). Even Tykerb works better with other things other than Xyloda.

They should have tested it against a taxane with Herceptin.