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Old 05-22-2012, 09:07 AM   #1
AliciaB
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Her2 +++

Okay, so I need to look more closely at my path report.
But does the degree of HER2 make a difference? What about degree of Er+ and Pr+?
I know I am triple positive but .......
More scary things to worry about .....shit!
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Old 05-22-2012, 01:05 PM   #2
Becky
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Re: Her2 +++

Some pathology reports state the % positive the ER and PR is. For example, I am ER 50% and PR negative.

Some also report it much the same as Her2 - ER+++, PR++ (meaning in normal speak, ER highly positive, PR medium positive).

Does yours say anything else like the above?
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Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
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NED 9 years!

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Old 05-22-2012, 05:39 PM   #3
phil
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Re: Her2 +++

receptor status guides tx. my wife is strong her2, but we know a woman who is triple pos, who has gottten good response from her2 drugs like herc itself , and tykerb. Has used er + drugs as well. various combos for many yrs , since early 2000's . My overall advice is , if you have metastatic bc , it is by definition aggressive, so get aggressive tx at a leading research hospital, if possible. With a bc specialist ( so many see generalist oncologists ). Dont hesitate to get second opinions.
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Old 05-23-2012, 03:40 PM   #4
tricia keegan
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Re: Her2 +++

I'm highly triple pos and as Becky mentioned something like 90% er/pr/her2 but still doing well and approaching seven years out next month
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Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly
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Old 05-23-2012, 09:40 PM   #5
AliciaB
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Re: Her2 +++

So I looked at my path report, it does not say anything about the intensity of HER2 other than that I am positive. Does the degree or intensity of HER2 make a difference in terms of reoccurance or is positive simply positive?

I am 96% ER positive. Can't recall % on pr.
Not sure I consider my cancer metastic. I have 1/4 positive lymph node with local extension. CT ( chest?) and bone scan clear.
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Old 05-24-2012, 10:18 AM   #6
phil
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Re: Her2 +++

Our doc never said anything about level of her2 in 06 , at dx. But to get t dm-1 , they referred to path rpt, a "6 " on the FISH scale, w any reading above a 3 to be significant for response to herceptin t dm-1. Plus Lorraine is only her2. My hunch is that t dm-1 works best w. pure her2 overexpression, easier target ?? . May not work as well w/ some er +, pr + , mixed in. should still be tried w/ any high her2 as late stage tx. Maybe when approved , it will be used in diff. combos to hit other types of bc..
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Old 05-24-2012, 07:35 PM   #7
AliciaB
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Re: Her2 +++

Phil- are yo the main support for your wife? Do you have children at home? I am looking to chat with a husband of a wife with bc.

Also, what is dm-1?
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Old 05-25-2012, 08:09 AM   #8
Jackie07
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Re: Her2 +++

Alicia,

There's some very good information about Her2+++ breast cancer listed in the Homepage. Below is the link to the portion where Her2+, Her2++, Her2+++ are explained.

http://her2support.org/her2-breast-c...s-a-treatments

T-DM1 is a new treatment 'method' for Her2 +++ breast cancer. T= Trastuzumab = Herceptin = targeted medicine for Her2 positive (+++) breast cancer

T-DM1 uses Herceptin to deliver a special 'something' directly to the cancer cells that are Her2+++, so it has less side effects and more effective. There are expanded trials available in many cancer centers. And we've been hoping it will be approved by the FDA soon. You can find more discussions on T-DM1 using the 'Search' button on top.
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http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
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NICU 4.4 LB
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Cntrl Neurocytoma 4x5x6.5 cm Craniotomy 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
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Last edited by Jackie07; 05-25-2012 at 02:16 PM..
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Old 05-25-2012, 09:02 AM   #9
Rolepaul
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Re: Her2 +++

TDM-1 is Herceptin conjugated (chemically bound to) Mayastine. Mayastine is too toxic to be given IV. When tied to the Herceptin (which only binds to Her+ receptors on the cancer cells) can deliver the Mayastine directly to the cancer cells with less side effects. Herceptin is a Monoclonal Antibody (MAb) that is derived from taking Her+ cell proteins and fusing them with mammalian cells to make a cell line that makes the proteins called Monoclonal Antibodies. I did some of the first work on diagnostic MAbs back in the mid 1980s. I also did some of the first work on conjugation at the same time. So yes I do know what I am talking about. I followed HER + going to the brain after Nov 2009 when my wife Nina was found to have it. I get information that others cannot. I am not as knowledgeable about Xeloda and Tykerb as others in the pharm industry, but I am not bad. GSK corporate is 15 miles down the road and Tykerb was developed there. I have talked to the development team face to face. I think I can provide good information to those that want it. As for the French 5% brain mets for BC, the most current thought is 30% for HER+. Please test for it early as the ablve articles all attribute success to early intervention.

Paul
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Old 05-25-2012, 11:37 AM   #10
MJsHusband
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Re: Her2 +++

AliciaB,
I am the husband of a wife with bc. Feel free to chat with me whenever. ~Greg
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08/10 ~ Dx IBC, Her2+++ ER-/PR- Stage 4, mets to liver. Age 43.
08/10 ~ Began 12 weeks of Taxetere/Carboplatin/Herceptin tx
[10/10 ~ Scans show liver lesions are gone. NED!
11/10 ~ Ended chemo. Herceptin-only tx
01/11 ~ Mastectomy
03/11 ~ Radiation
07/11 ~ Reconstructive surgery
10/11 ~ PET/CT shows NED :)
01/12 ~ Malignant tumors found in uterus, cervix, fallopian tubes and lymph nodes. Dx as endometrial cancer. Stage III2c
02/12 ~Hysterectomy(all tumors removed). Back to NED.
02/12 ~ Final Herceptin treatment.
03/12 ~ Began Cisplatin/Adriamycin tx for endometrial cancer.
03/12 ~ Tumors dx her2 metastisis, not entdometrial cancer. Back to BC tx.
03/12 ~ CT scan shows NED. :)
04/12/~ Began Tykerb/Xeloda.
06/12 ~ Ended Xeloda. Continuing Tykerb. Still NED.
09/12 ~ PET/CT scans show NED. : )
04/13 ~ Rash on original breast biopsied as cancer.
05/13 ~ Surgery to remove skin and tissue around rash. Continue Tykerb.
06/13 ~ PET/CT scans show NED : )
11/13 ~ Jaundice eyes and skin. CT scan show mets to liver as well as peritoneal carcinomatosis with malignant ascites. Began Abraxane/Herceptin tx.
02/14 ~ CT scan shows NED. :)

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Old 05-25-2012, 12:46 PM   #11
phil
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Re: Her2 +++

I have one young adult still at home, 24 yo son. 3 older daughters, with 5 grandch., 2 more on the way ! My first wife passed away from bc in '92. battling met. bc since '06 w/ second wife. happy to share my experience w/ you, others .
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