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Old 04-18-2012, 01:37 PM   #1
Christine MH-UK
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Smile Scientists Identify 10 Different Types of Breast Cancer

Interesting Story from Business Week on why this study may help to improve clinical trials:
http://www.businessweek.com/news/201...types-in-study

More detail from Cancer Research UK, which funded the study:
http://scienceblog.cancerresearchuk....-and-r-landing
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Old 04-19-2012, 10:40 AM   #2
Ellie F
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Re: Scientists Identify 10 Different Types of Breast Cancer

Thanks for posting. Heard this on the news yesterday and so was very interested to understand more about how it broke down.
Ellie
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Old 04-20-2012, 11:25 AM   #3
AlaskaAngel
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Re: Scientists Identify 10 Different Types of Breast Cancer

Thank you very much, Christine MH-UK.

AlaskaAngel
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Old 05-04-2012, 09:57 PM   #4
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How Long Until Progress Reaches the Clinic?

I like what Dr. Elaine Schattner had to say about this. The mainstay of treatment would be a cocktail of drugs, by mouth, like patients take for hepatitis C, tuberculosis or AIDS.

http://www.huffingtonpost.com/elaine...b_1472528.html

Cocktails have become standard treatment in many oncological protocols: concoctions of two or more powerful cytotoxic agents which supposedly will attack the tumor in different ways. The ability of various agents to kill tumor and/or microvascular cells (anti-angiogenesis) in the same tumor specimen is highly variable among the different agents. There are so many agents out there now, doctors have a confusing array of choices. They don't know how to mix them together in the right order.

A diagnosis of AIDS was a death sentence until the advent of drug cocktails in the 1990s, which helped patients suppress the disease indefinitely. Now researchers say a similar combination strategy may change the course of cancer.

The application of synergy analyses (drug cocktails) may represent one of the most important applications of the functional cytometric profiling platform, enabling the exploration of both anticipated and unanticipated favorable interactions. Equally important may be the capacity to study drug antagonism wherein two effective drugs counteract each others’ benefits. This phenomenon, characterized by the whole being less than the sum of the parts, represents a major pitfall for clinical trialists who simply combine drugs “because they can.”

These analyses are revolutionizing the way newer classes of drugs are applied and has the potential to accelerate drug development and clinical therapeutics. Good outcomes require good drugs, but better outcomes require good combinations. Intelligent combinations are a principle focus of the functional cytometric profiling platform. It strives to identify the best outcomes for patients (not populations of patients).

Arnold Glazier, M.D., former Oncology Fellow at Johns Hopkins, said in his book Cure: Scientific, Social and Organizational Requirements for the Specific Cure of Cancer," the consistent and specific cure or control of cancer will require multiple drugs administered in combination targeted to abnormal patterns of normal cellular machinery that effect or reflect malignant behavior. Finding the 'patterns' of malignant cells and developing a set of 5 to10 drugs in order to cure or control cancer."

http://cancerfocus.org/forum/showthread.php?t=3371

Last edited by gdpawel; 05-19-2012 at 12:31 PM.. Reason: correct url address
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Old 05-04-2012, 10:47 PM   #5
Rich66
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Re: Scientists Identify 10 Different Types of Breast Cancer

Better than previous suggestions of "thousands". But..idealist I am, hope there can be an upstream common target/achilles heel not only within a given cancer, but across cancer types. No idea if it will play out as such..but Genspera's G202 is one of few that purports to approach cancer at a level beyond the myriad permutations that keep labs busy but progress limited.
But hey..if a manageable rotation of 5 to 10 drugs can suffice..I'm all in.
Worth noting that viral approaches, including one of the early AIDS drugs, Viracept/Nefilnavir, have been showing efficacy in various cancers. Maybe we should be trying those AIDS "cocktails" on cancer.
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Old 05-05-2012, 06:43 AM   #6
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Re: Scientists Identify 10 Different Types of Breast Cancer

Dr. Phillip Dennis and colleagues did exactly that: they took existing HIV protease inhibitor drugs and tested 6 of them against cancer cell lines derived from 9 different human tumor types and found that three of the drugs (ritonavir, nelfinavir and saquinavir) reduced the growth of 60 of those cell lines.

In the laboratory, nelfinavir or Viracept, a first generation speific protease inhibitor designed for HIV appeared most potent (Autophagy 4(1):107-9, 2008).

http://cancerx.wordpress.com/2011/01...o-anti-cancer/

Tumor-Cell Death, Autophagy, and Immunity

http://cancerfocus.org/forum/showthread.php?t=3651

Last edited by gdpawel; 05-19-2012 at 12:34 PM.. Reason: correct url address
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