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Breast Cancer Meeting Highlights News fro recent ASCO and San Antonio Meetings

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Old 01-04-2012, 03:03 PM   #1
Hopeful
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Mammographic Microcalcifications and Breast Cancer Tumorigenesis

Abstract: http://www.abstracts2view.com/sabcs1...=SABCS11L_1070

Poster: http://www.abstracts2view.com/sabcs1...hp?nu=P5-08-04

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Old 01-04-2012, 04:14 PM   #2
Laurel
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Re: Mammographic Microcalcifications and Breast Cancer Tumorigenesis

"This is the largest study that suggests the appearance of MCs on mammograms is strongly associated with HER-2 overexpression, invasive ductal carcinoma and perimenopausal status."

This fits me to a " T." Interesting study. Thanks, Hopeful.
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Old 01-04-2012, 05:56 PM   #3
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Re: Mammographic Microcalcifications and Breast Cancer Tumorigenesis

Fits me too. Sheesh. There's no doubt in my mind now that the 2006 core needle biopsy missed the cancer (just like the current one, except that this time, I was lucky enough to have a surgical oncologist who was on the ball).

Thanks again, Hopeful, for all these great articles.
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2/6/09 - Core needle biopsy: negative; Mammos through 2010: no change
3/30/11 - Pea-sized lump in left breast at site of prior biopsy; mammo negative, sonogram not so much
4/14/11 - Core needle biopsy: negative for cancer
5/18/11 - Excisional biopsy 1.2 cm tumor, LVI, positive margin; ER+60%,PR+20%,HER2/CEP17 5
6/15/11 - BMX: Left DCIS & LH; Right ADH; SNB: 2/3 nodes: 1.4 cm and 1 mm; ALND L1&2: 0/10; Stage IIa, Grade 3
7/14/11 - CT/Bone scans NED; MUGA 66%
7/19/11 - Biweekly dd AC w/Neulasta; done 8/30/11
9/13/11 - Transfusion (Hemoglobin 8.6); MUGA 64%
9/20/11 - Start Taxol + Herceptin; Taxol done 12/6/2011; continue Herceptin until 9/4/2012
12/27/11 - Radiation - 6 weeks; 2/27/2012 - DONE! Yayyyy!
2/29/12 - Start Tamoxifen 20 mg/day; continue until 2/28/17
5/16/12 - Start five-years Metformin trial
6/19/12 - MUGA 61%
8/21/12 - Brain MRI NED (head still hurts, brain still fogged)
9/4/12 - Herceptin done!
9/6/12 - Port out!
7/11/13 - Aricept 5mg for cognitive impairment; increased to 10mg as of 8/23/13
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Old 01-05-2012, 07:20 AM   #4
Hopeful
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Re: Mammographic Microcalcifications and Breast Cancer Tumorigenesis

I had micro calcs, too, show up in my annual mammo, which directed the radiologist to an "architectural distortion" in the breast, which lead to dx. It would be interesting to learn what the association is.

Rhonda, I am a researcher at heart, and like to poke around in the abstracts and posters presented at the various symposiums. About a third of what catches my eye is either too technical or does not provide additional info to me, about a third is of interest primarily to me, and the other third I think enough others would like to read, so I post those. Hope they are useful.

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Old 01-05-2012, 02:17 PM   #5
Becky
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Re: Mammographic Microcalcifications and Breast Cancer Tumorigenesis

You're always so goood Hopeful. I just had a 2cm tumor show up - no denying it. But clustered micro calcifications is a bad sign.
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Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
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Old 01-05-2012, 03:38 PM   #6
Hopeful
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Re: Mammographic Microcalcifications and Breast Cancer Tumorigenesis

For years I have had benign, large calcificiations in both breasts. I have read somewhere along the way that one of cancer's manifestations is a disregulation of the calcium channel. Maybe this is visible evidence?

Becky, right back at you for all you do for this community.

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Old 01-05-2012, 04:26 PM   #7
Becky
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Re: Mammographic Microcalcifications and Breast Cancer Tumorigenesis

I also have large "boulder" calcifications but never small nor clustered. The docs say that this is the way I am (and my mom(who had bc) and non cancer sister is this way too). Who knows?
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Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Zometa every 6 months for osteopenia

NED 9 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 04-26-2012, 04:32 AM   #8
aliza
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Re: Mammographic Microcalcifications and Breast Cancer Tumorigenesis

Think Pink, Live Green is a way of living that aims to help women reduce their risk of breast cancer or the disease coming back in survivors. It’s also a way for women living with advanced disease to make the healthiest choices possible.
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