04-17-2011, 12:56 PM
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#2
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: In Lab: Curcumin active against Her2 and may overcome Herceptin Resistance
Quote:
In this preliminary study, we showed curcumin decrease the viability of various breast cancer cell lines (MCF-7, MDAMB-231, MCF-10A, BT-474 and SKBr-3(herceptin resistant, hr)). The combination of curcumin did not interfere with the action of herceptin. The herceptin sensitive BT-474 and herceptin resistant SKBr-3(hr) were all sensitive to curcumin treatment. In western blot analysis, the phosphorylation of HER-2, Akt, MAPK were reduced in BT-474 cells when treated with herceptin. In SKBr-3(hr) cells, the addition of herceptin did not downregulate the phosphorylation of HER-2, Akt, and MAPK. When treated with curcumin, the phosphorylation of HER-2, Akt, and MAPK of SKBr-3(hr) were decreased combined with the downregulation of HER-2 oncoprotein in a dose and time dependent manner.
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